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Mouse Anti-CD79A Recombinant Antibody (CBFYC-0175) (CBMAB-C0198-FY)

This product is mouse antibody that recognizes CD79A. The antibody CBFYC-0175 can be used for immunoassay techniques such as: FC, IHC, WB.
See all CD79A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0175
Antibody Isotype
IgG1
Application
FC, IHC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to 202-216 amino acid sequence of human mb-1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD79a Molecule
Introduction
CD79A (CD79a Molecule) is a Protein Coding gene. Diseases associated with CD79A include Agammaglobulinemia 3, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
Entrez Gene ID
973
UniProt ID
P11912
Alternative Names
CD79a Molecule; Membrane-Bound Immunoglobulin-Associated Protein; CD79A Antigen (Immunoglobulin-Associated Alpha); CD79a Molecule, Immunoglobulin-Associated Alpha; Surface IgM-Associated Protein; MB-1 Membrane Glycoprotein; Ig-Alpha
Function
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
B cell activation Source: UniProtKB
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
B cell receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Involvement in disease
Agammaglobulinemia 3, autosomal recessive (AGM3): The disease is caused by variants affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein. A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Topology
Extracellular: 33-143
Helical: 144-165
Cytoplasmic: 166-226
PTM
Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).

Julamanee, J., Terakura, S., Umemura, K., Adachi, Y., Miyao, K., Okuno, S., ... & Kiyoi, H. (2021). Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival. Molecular Therapy.

Lenk, L., Carlet, M., Vogiatzi, F., Spory, L., Winterberg, D., Cousins, A., ... & Schewe, D. M. (2021). CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications biology, 4(1), 1-6.

Replicating, R. N. A. (2021). CD79A/CD40 endodomain enhances CAR-T persistence. Molecular Therapy, 29(9), 2627.

Berhili, A., Bensalah, M., ElMalki, J., Elyagoubi, A., & Seddik, R. (2021). Immunophenotypic challenges in diagnosis of CD79a negativity in a patient with B acute lymphoblastic leukemia harboring intrachromosomal amplification of chromosome 21: a case report. Journal of Medical Case Reports, 15(1), 1-6.

Mangogna, A., Cox, M. C., Ruco, L., Lopez, G., Belmonte, B., & Di Napoli, A. (2020). Rituximab plus chemotherapy provides no clinical benefit in a peripheral T-Cell lymphoma not otherwise specified with aberrant expression of CD20 and CD79a: a case report and review of the literature. Diagnostics, 10(6), 341.

Langereis, J. D., Henriet, S. S., Kuipers, S., Weemaes, C. M., van der Burg, M., de Jonge, M. I., & van der Flier, M. (2018). IgM augments complement bactericidal activity with serum from a patient with a novel CD79a mutation. Journal of clinical immunology, 38(2), 185-192.

Li, H., Li, Y., Zhang, X., Wang, Y., Zhang, W., Wu, X., & Wang, Z. (2017). Molecular characterization of the CD79a and CD79b and its role against Aeromonas hydrophila infection in Chinese sucker (Myxocyprinus asiaticus). Fish physiology and biochemistry, 43(6), 1571-1585.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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