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Rat Anti-CD83 Recombinant Antibody (1G11) (CBMAB-C4133-LY)

This product is antibody recognizes CD83. The antibody 1G11 immunoassay techniques such as: WB, FC.
See all CD83 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
1G11
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD83 Molecule
Introduction
CD83 (CD83 Molecule) is a Protein Coding gene. Diseases associated with CD83 include Plague and Rift Valley Fever. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and T cell receptor signaling pathway.
Entrez Gene ID
UniProt ID
Alternative Names
CD83 Molecule; CD83 Antigen (Activated B Lymphocytes, Immunoglobulin Superfamily); Cell Surface Protein HB15; B-Cell Activation Protein; CD83 Antigen; HCD83; Cell-Surface Glycoprotein; BL11; HB15;
Function
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
Biological Process
Defense response Source: ProtInc
Humoral immune response Source: ProtInc
Negative regulation of interleukin-4 production Source: Ensembl
Positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of interleukin-2 production Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Membrane
Topology
Extracellular: 20-144
Helical: 145-166
Cytoplasmic: 167-205

Shrestha, A., Sadeyen, J. R., Lukosaityte, D., Chang, P., Smith, A., Van Hulten, M., & Iqbal, M. (2021). Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza. npj Vaccines, 6(1), 1-12.

Grosche, L., Knippertz, I., König, C., Royzman, D., Wild, A. B., Zinser, E., ... & Lechmann, M. (2020). The CD83 Molecule–An Important Immune Checkpoint. Frontiers in immunology, 11, 721.

Batool, A., Liu, H., Liu, Y. X., & Chen, S. R. (2020). CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate. Cancers, 12(8), 2269.

Islam, S. M., Byun, H. O., Choi, B., & Sohn, S. (2019). Inhibition of CD83 alleviates systemic inflammation in herpes simplex virus type 1-induced Behcet’s disease model mouse. Mediators of inflammation, 2019.

Zinser, E., Naumann, R., Wild, A. B., Michalski, J., Deinzer, A., Stich, L., ... & Knippertz, I. (2019). Endogenous expression of the human CD83 attenuates EAE symptoms in humanized transgenic mice and increases the activity of regulatory T cells. Frontiers in immunology, 10, 1442.

Nombela, I., Requena-Platek, R., Morales-Lange, B., Chico, V., Puente-Marin, S., Ciordia, S., ... & Ortega-Villaizan, M. D. M. (2019). Rainbow trout red blood cells exposed to viral hemorrhagic septicemia virus up-regulate antigen-processing mechanisms and MHC I&II, CD86, and CD83 antigen-presenting cell markers. Cells, 8(5), 386.

Wild, A. B., Krzyzak, L., Peckert, K., Stich, L., Kuhnt, C., Butterhof, A., ... & Steinkasserer, A. (2019). CD83 orchestrates immunity toward self and non-self in dendritic cells. JCI insight, 4(20).

Huo, S., Zhang, J., Wu, F., Zuo, Y., Cui, D., Li, X., ... & Zhong, F. (2019). Porcine CD83 is a glycosylated dimeric protein existing naturally in membrane-bound and soluble forms. Developmental & Comparative Immunology, 90, 60-69.

Lin, W., Buscher, K., Wang, B., Fan, Z., Song, N., Li, P., ... & Bi, H. (2018). Soluble CD83 alleviates experimental autoimmune uveitis by inhibiting filamentous actin-dependent calcium release in dendritic cells. Frontiers in immunology, 9, 1567.

Mo, Z. Q., Wang, J. L., Yang, M., Ni, L. Y., Wang, H. Q., Lao, G. F., ... & Dan, X. M. (2017). Characterization and expression analysis of grouper (Epinephelus coioides) co-stimulatory molecules CD83 and CD80/86 post Cryptocaryon irritans infection. Fish & shellfish immunology, 67, 467-474.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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