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Rat Anti-CD8A Recombinant Antibody (3H870) (CBMAB-C1242-LY)

This product is antibody recognizes CD8A. The antibody 3H870 immunoassay techniques such as: FC, IHC.
See all CD8A antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
3H870
Antibody Isotype
IgG2a
Application
FC, IHC

Basic Information

Immunogen
T cell clone, C6
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD8a Molecule
Introduction
CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include Cd8 Deficiency, Familial and Primary Cutaneous Aggressive Epidermotropic Cd8+ T-Cell Lymphoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and T-Cell Receptor and Co-stimulatory Signaling.
Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and coreceptor activity.
Entrez Gene ID
UniProt ID
Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Biological Process
Antigen processing and presentation Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Cytotoxic T cell differentiation Source: GO_Central
Immune response Source: UniProtKB
Regulation of immune response Source: Reactome
T cell activation Source: UniProtKB
T cell mediated immunity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane. CD8A localizes to lipid rafts only when associated with its partner CD8B.
Isoform 2: Secreted
Involvement in disease
CD8 deficiency, familial (CD8 deficiency): An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
Topology
Extracellular: 22-182
Helical: 183-203
Cytoplasmic: 204-235
PTM
Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
O-glycosylated.
Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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