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Mouse Anti-CDH11 Recombinant Antibody (CBYY-C1723) (CBMAB-C3161-YY)

This product is mouse antibody that recognizes CDH11. The antibody CBYY-C1723 can be used for immunoassay techniques such as: ELISA, WB, IHC-P, IF, FC
See all CDH11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1723
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P, IF, FC

Basic Information

Immunogen
Recombinant fragment of human CDH11 (AA: 468-617) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Preservative
PBS
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cadherin 11
Entrez Gene ID
UniProt ID
Alternative Names
Cyclin Dependent Kinase 1; Cell Division Cycle 2, G1 To S And G2 To M; Cell Division Control Protein 2 Homolog; Cell Division Protein Kinase 1; P34 Protein Kinase; P34CDC2; CDC28A;
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Biological Process
Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Corticospinal tract morphogenesis Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Modulation of chemical synaptic transmission Source: Ensembl
Multicellular organism development Source: GO_Central
Ossification Source: UniProtKB
Skeletal system development Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Elsahy-Waters syndrome (ESWS): An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.
Topology
Extracellular: 54-617
Helical: 618-640
Cytoplasmic: 641-796

Chen, X., Xiang, H., Yu, S., Lu, Y., & Wu, T. (2021). Research progress in the role and mechanism of Cadherin-11 in different diseases. Journal of Cancer, 12(4), 1190.

Cao, W., Song, S., Fang, G., Li, Y., Wang, Y., & Wang, Q. S. (2021). Cadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation. Journal of Inflammation Research, 14, 2897.

Johnson, C. L., Riley, L., Bersi, M., Linton, M. F., & Merryman, W. D. (2021). Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H756-H769.

Manohar, S., Camacho-Magallanes, A., Echeverria Jr, C., & Rogers, C. D. (2020). Cadherin-11 is required for neural crest specification and survival. Frontiers in physiology, 11.

Wang, T., Zhou, Q., & Shang, Y. (2020). MiRNA-451a inhibits airway remodeling by targeting Cadherin 11 in an allergic asthma model of neonatal mice. International immunopharmacology, 83, 106440.

Satriyo, P. B., Bamodu, O. A., Chen, J. H., Aryandono, T., Haryana, S. M., Yeh, C. T., & Chao, T. Y. (2019). Cadherin 11 inhibition downregulates β-catenin, deactivates the canonical WNT signalling pathway and suppresses the cancer stem cell-like phenotype of triple negative breast cancer. Journal of clinical medicine, 8(2), 148.

Yuan, S., Li, L., Xiang, S., Jia, H., & Luo, T. (2019). Cadherin-11 is inactivated due to promoter methylation and functions in colorectal cancer as a tumour suppressor. Cancer management and research, 11, 2517.

Pedroza, M., To, S., Smith, J., & Agarwal, S. K. (2019). Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride. PloS one, 14(7), e0218971.

Bowler, M. A., Bersi, M. R., Ryzhova, L. M., Jerrell, R. J., Parekh, A., & Merryman, W. D. (2018). Cadherin-11 as a regulator of valve myofibroblast mechanobiology. American Journal of Physiology-Heart and Circulatory Physiology, 315(6), H1614-H1626.

Zhu, Q., Wang, Z., Zhou, L., Ren, Y., Gong, Y., Qin, W., ... & Wang, T. (2018). The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncology letters, 15(2), 1417-1422.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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