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Mouse Anti-CDKN2C Recombinant Antibody (18P118 DCS-118) (CBMAB-C3466-LY)

This product is antibody recognizes CDKN2C. The antibody 18P118 DCS-118 immunoassay techniques such as: IF, IHC-P, IP, WB.
See all CDKN2C antibodies
Published Data
Fig.1 Downregulation of p18INK4c at senescence.
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Fig.2 Regulation of p18INK4c by E2F1.
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Fig.3 Distinction between activation and delayed repression.
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Fig.4 Senescence-dependent and -independent downregulation of p18INK4c.
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Fig.5 p18INK4c is not required for replicative or oncogene-induced senescence.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
18P118 DCS-118
Antibody Isotype
IgG1
Application
IF, IHC-P, IP, WB

Basic Information

Immunogen
Purified recombinant p18INK4c protein
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.2% BSA
Preservative
0.09% sodium azide
Concentration
0.4 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin Dependent Kinase Inhibitor 2C
Introduction
CDKN2C (Cyclin Dependent Kinase Inhibitor 2C) is a Protein Coding gene. Diseases associated with CDKN2C include Oligodendroglioma and Choriocarcinoma Of The Testis. Among its related pathways are Cellular Senescence (REACTOME) and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity.
An important paralog of this gene is CDKN2D.
Entrez Gene ID
Human1031
Mouse12580
UniProt ID
HumanP42773
MouseQ60772
Function
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Biological Process
Cell cycle arrest Source: BHF-UCL
G1/S transition of mitotic cell cycle Source: BHF-UCL
Negative regulation of cell growth Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
Negative regulation of phosphorylation Source: BHF-UCL
Oligodendrocyte differentiation Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Cellular Location
Cytosol; Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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