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Mouse Anti-CEACAM6 Recombinant Antibody (1G2) (CBMAB-C4147-LY)

This product is antibody recognizes CEACAM6. The antibody 1G2 immunoassay techniques such as: ELISA, IF, WB.
See all CEACAM6 antibodies
Published Data
Fig.1 CEACAM6 expression analysis by Western Blot. E. coli strains 11G5 and 14H4 were isolated from colon cancer patients and E. coli strains 9F1 and 15C1 from patients with diverticulosis.
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Fig.2 CEACAM6 expression in lung adenocarcinoma specimens and its relationship to overall survival.
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Fig.3 MiR-29a targets CEACAM6 directly in lung adenocarcinoma cells.
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Fig.4 Western blot analyses of CEACAM6 expression in A549 tumors from mice injected with control vectorexpressing cells (A549/C) or miR-29a-expressing cells.
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Fig.5 CEACAM6 expression analysis by Western Blot.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G2
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 6
Introduction
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Entrez Gene ID
4680
UniProt ID
P40199
Alternative Names
Carcinoembryonic Antigen Related Cell Adhesion Molecule 6; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen); Normal Cross-Reacting Antigen; NCA; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6; Non-Specific Crossreacting Antigen;
Function
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051).
Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051).
Heterophilic interaction with CEACAM8 oCcurs in activated neutrophils (PubMed:8776764).
Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450).
Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051).
Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).
Biological Process
Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
Signal transduction Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.
PTM
Glycosylated.

An, F., Zheng, C., Zhang, G., Zhou, L., Wu, Y., Hou, Z., ... & Zhan, Q. (2021). Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 Promotes Carcinogenesis of Gastric Cancer and Anti-CEACAM6 Fluorescent Probe Can Diagnose the Precancerous Lesions. Frontiers in Oncology, 11.

Rahman, S. K., Ansari, M. A., Gaur, P., Ahmad, I., Chakravarty, C., Verma, D. K., ... & Lal, S. K. (2021). The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza a Virus. Viruses, 13(5), 726.

Tian, C., Zhang, B., & Ge, C. (2020). Effect of CEACAM6 silencing on the biological behavior of human gallbladder cancer cells. Oncology Letters, 20(3), 2677-2688.

Zhu, R., Ge, J., Ma, J., & Zheng, J. (2019). Carcinoembryonic antigen related cell adhesion molecule 6 promotes the proliferation and migration of renal cancer cells through the ERK/AKT signaling pathway. Translational andrology and urology, 8(5), 457.

Pandey, R., Zhou, M., Islam, S., Chen, B., Barker, N. K., Langlais, P., ... & Mahadevan, D. (2019). Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target. Scientific reports, 9(1), 1-14.

Iwabuchi, E., Miki, Y., Onodera, Y., Shibahara, Y., Takagi, K., Suzuki, T., ... & Sasano, H. (2019). Co-expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 inhibits proliferation and invasiveness of breast carcinoma cells. Clinical & experimental metastasis, 36(5), 423-432.

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., ... & Wu, M. H. (2018). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. Oncogene, 37(1), 116-127.

Rizeq, B., Zakaria, Z., & Ouhtit, A. (2018). Towards understanding the mechanisms of actions of carcinoembryonic antigen‐related cell adhesion molecule 6 in cancer progression. Cancer science, 109(1), 33-42.

Ru, G. Q., Han, Y., Wang, W., Chen, Y., Wang, H. J., Xu, W. J., ... & Huang, D. (2017). CEACAM6 is a prognostic biomarker and potential therapeutic target for gastric carcinoma. Oncotarget, 8(48), 83673.

Zang, M., Hu, L., Cao, S., Fan, Z., Pang, L., Li, J., ... & Liu, B. (2017). Dual role of carcinoembryonic antigen-related cell adhesion molecule 6 expression in predicting the overall survival of gastric cancer patients. Scientific reports, 7(1), 1-11.

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For research use only. Not intended for any clinical use.

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