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Mouse Anti-CFP Recombinant Antibody (10B2571) (CBMAB-C2198-LY)

This product is antibody recognizes CFP. The antibody 10B2571 immunoassay techniques such as: ELISA, IHC.
See all CFP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10B2571
Antibody Isotype
IgG1
Application
ELISA, IHC

Basic Information

Immunogen
Native purified factor P from human serum
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Complement Factor Properdin
Introduction
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
Entrez Gene ID
UniProt ID
Alternative Names
Complement Factor Properdin; Properdin P Factor, Complement; Complement Factor P; PFC; PROPERDIN; BFD; PFD;
Function
A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884).
It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884).
Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604).
Biological Process
Complement activation Source: Reactome
Complement activation, alternative pathway Source: Reactome
Defense response to bacterium Source: ProtInc
Immune response Source: ProtInc
Neutrophil degranulation Source: Reactome
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Properdin deficiency (PFD): Results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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