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Rabbit Anti-CGA Recombinant Antibody (RM330) (CBMAB-BR134LY)

The product is antibody recognizes CGA. The antibody RM330 immunoassay techniques such as: ELISA, IHC, WB.
See all CGA antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
RM330
Antibody Isotype
IgG
Application
ELISA: 1-5 μg/ml, IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
Native hCG protein purified from Human Urine
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 1% BSA
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glycoprotein Hormones, Alpha Polypeptide
Introduction
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Entrez Gene ID
UniProt ID
Alternative Names
Glycoprotein hormones alpha chain;Anterior pituitary glycoprotein hormones common subunit alpha;Choriogonadotropin alpha chain;Chorionic gonadotrophin subunit alpha;CG-alpha;Follicle-stimulating hormone alpha chain;FSH-alpha;Follitropin alpha chain;Luteinizing hormone alpha chain;LSH-alpha;Lutropin alpha chain;Thyroid-stimulating hormone alpha chain;TSH-alpha;Thyrotropin alpha chain;CGA;
Function
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Biological Process
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Peptide hormone processing Source: Reactome
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of steroid biosynthetic process Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of signaling receptor activity Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: Reactome
Thyroid hormone generation Source: GO_Central
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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