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Mouse Anti-CGB5 Recombinant Antibody (HCGb/459) (CBMAB-H0957-FY)

This product is mouse antibody that recognizes CGB5. The antibody HCGb/459 can be used for immunoassay techniques such as: ELISA, WB, IHC.
See all CGB5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
HCGb/459
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chorionic gonadotropin, beta polypeptide 5
Introduction
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.
Entrez Gene ID
93659
UniProt ID
P0DN86
Alternative Names
Chorionic Gonadotropin Beta Subunit 5; Chorionic Gonadotropin, Beta Polypeptide 5; CGB; Chorionic Gonadotropin Beta 5 Subunit; Chorionic Gonadotropin Chain Beta; Choriogonadotropin Subunit Beta
Function
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Biological Process
Apoptotic process Source: ProtInc
Cell-cell signaling Source: ProtInc
Female gamete generation Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Hormone-mediated signaling pathway Source: GO_Central
Peptide hormone processing Source: Reactome
Regulation of transcription by RNA polymerase II Source: Reactome
Signal transduction Source: ProtInc
Cellular Location
Secreted

Biskup, K., Blanchard, V., Castillo-Binder, P., Alexander, H., Engeland, K., & Schug, S. (2020). N-and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit. Glycoconjugate journal, 37(5), 599-610.

Śliwa, A., Kubiczak, M., Szczerba, A., Walkowiak, G., Nowak-Markwitz, E., Burczyńska, B., ... & Jankowska, A. (2019). Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer. BMC cancer, 19(1), 1-9.

Lintula, S., Mirtti, T., Rannikko, A., Bützow, A., Lempiäinen, A., Stenman, J., ... & Hotakainen, K. (2019). Tumor expression of human chorionic gonadotropin beta mRNA and prognosis of prostate cancer treated by radical prostatectomy. Scandinavian journal of clinical and laboratory investigation, 79(6), 424-430.

Yang, Y., Shi, Y., Hou, Y., Lu, Y., & Yang, J. (2018). CGB 5 expression is independently associated with poor overall survival and recurrence‐free survival in patients with advanced gastric cancer. Cancer medicine, 7(3), 716-725.

Babaei Houlari, B., & Salehi, Z. (2018). Analysis of the Relationship between CGB5 155G/C Polymorphism and in vitro Fertilization-embryo Transfer Outcome (IVF-ET) in the Iranian Population. Journal of Arak University of Medical Sciences, 20(10), 11-19.

Andrusiewicz, M., Skibińska, I., Gąsiorowska, E., Białas, P., & Kotwicka, M. (2017). Fluorescence resonance energy transfer usage to track the sequence promoter changes in CGB5 gene in ovarian cancer patients. Biomedicine & Pharmacotherapy, 90, 139-146.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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