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Rabbit Anti-CHAT Recombinant Antibody (EPR16590) (CBMAB-1356-CN)

This product is a rabbit antibody that recognizes CHAT of pig. The antibody EPR16590 can be used for immunoassay techniques such as: IHC-P, WB.
See all CHAT antibodies

Summary

Host Animal
Rabbit
Specificity
Pig, Mouse, Rat, Rabbit, Guinea pig
Clone
EPR16590
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide within Pig Choline Acetyltransferase aa. 150-250.
Specificity
Pig, Mouse, Rat, Rabbit, Guinea pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ChAT
Introduction
Choline O-acetyltransferase (CHAT) catalyzes the biosynthesis of the neurotransmitter acetylcholine. CHAT is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Mutations in CHAT gene are associated with congenital myasthenic syndrome associated with episodic apnea, Alzheimer's disease and mild cognitive impairment.
Entrez Gene ID
Pig396896
Mouse12647
Rat290567
Guinea pig100718930
Rabbit100342226
UniProt ID
PigP13222
MouseQ03059
RatP32738
Guinea pigH0V586
RabbitG1TI83
Alternative Names
ChoAcTase
Function
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Biological Process
Acetylcholine biosynthetic process Source: GO_Central
Neuromuscular synaptic transmission Source: GO_Central
Neurotransmitter transport Source: Reactome
Phosphatidylcholine biosynthetic process Source: Reactome
Cellular Location
Cytosol; Nucleus; Cytoplasm; Neuron projection; Synapse
Involvement in disease
Myasthenic syndrome, congenital, 6, presynaptic (CMS6): A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS6 affected individuals have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. CMS6 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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