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Mouse Anti-CHP2 Antibody (4BA10) (CBMAB-1067CQ)

This product is a mouse antibody that recognizes CHP2. The antibody 4BA10 can be used for immunoassay techniques such as: ELISA, WB.
See all CHP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4BA10
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcineurin Like EF-Hand Protein 2
Introduction
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity.
Entrez Gene ID
63928
UniProt ID
O43745
Alternative Names
HCA520
Function
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Biological Process
Cellular response to calcium ion Source: UniProtKB
Positive regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of phosphatase activity Source: UniProtKB
Positive regulation of protein import into nucleus Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Protein transport Source: UniProtKB-KW
Cellular Location
Cell membrane; Nucleus; Cytoplasm. Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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