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Mouse Anti-CHRNA4 Recombinant Antibody (4E3) (CBMAB-1372-CN)

This product is a mouse antibody that recognizes CHRNA4 of human. The antibody 4E3 can be used for immunoassay techniques such as: WB, ELISA.
See all CHRNA4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E3
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Immunogen
CHRNA4 (NP_000735, aa. 29-128) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1x PBS,  pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in aa. 29-128

Target

Full Name
cholinergic receptor, nicotinic, alpha 4
Introduction
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.
Entrez Gene ID
1137
UniProt ID
P43681
Alternative Names
EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Biological Process
Action potential Source: UniProtKB
B cell activation Source: UniProtKB
Behavioral response to nicotine Source: UniProtKB
Calcium ion transport Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Cognition Source: UniProtKB
DNA repair Source: UniProtKB
Inhibitory postsynaptic potential Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Membrane depolarization Source: UniProtKB
Nervous system process Source: UniProtKB
Regulation of dopamine secretion Source: UniProtKB
Regulation of membrane potential Source: UniProtKB
Response to hypoxia Source: UniProtKB
Response to nicotine Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Sensory perception of pain Source: UniProtKB
Signal transduction Source: UniProtKB
Synaptic transmission, cholinergic Source: UniProtKB
Cellular Location
Postsynaptic cell membrane; Cell membrane
Involvement in disease
Epilepsy, nocturnal frontal lobe, 1 (ENFL1): An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
Topology
Extracellular: 29-242
Helical: 243-267
Helical: 275-293
Helical: 309-330
Cytoplasmic: 331-600
Helical: 601-619
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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