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Mouse Anti-CHRNB2 (AA 26-130) Recombinant Antibody (CBFYC-1857) (CBMAB-C1921-FY)

This product is mouse antibody that recognizes CHRNB2. The antibody CBFYC-1857 can be used for immunoassay techniques such as: ELISA, WB.
See all CHRNB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1857
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 26-130

Target

Full Name
cholinergic receptor, nicotinic, beta 2 (neuronal)
Introduction
Neuronal acetylcholine receptors are homo-or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.
Entrez Gene ID
1141
UniProt ID
P17787
Alternative Names
Cholinergic Receptor Nicotinic Beta 2 Subunit; Cholinergic Receptor, Nicotinic, Beta Polypeptide 2 (Neuronal); Acetylcholine Receptor, Nicotinic, Beta 2 (Neuronal); Cholinergic Receptor, Nicotinic, Beta 2 (Neuronal); Cholinergic Receptor, Nicotinic Beta 2; Beta2 Human Neuronal Nicotinic Acetylcholine Receptor
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Biological Process
Acetylcholine receptor signaling pathway Source: ARUK-UCL
Associative learning Source: UniProtKB
B cell activation Source: UniProtKB
Behavioral response to nicotine Source: UniProtKB
Calcium ion transport Source: UniProtKB
Central nervous system projection neuron axonogenesis Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Cognition Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Lateral geniculate nucleus development Source: UniProtKB
Learning Source: UniProtKB
Locomotory behavior Source: UniProtKB
Membrane depolarization Source: UniProtKB
Memory Source: UniProtKB
Negative regulation of action potential Source: UniProtKB
Nervous system process Source: UniProtKB
Optic nerve morphogenesis Source: UniProtKB
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of dopamine secretion Source: UniProtKB
Regulation of circadian sleep/wake cycle, REM sleep Source: UniProtKB
Regulation of dendrite morphogenesis Source: UniProtKB
Regulation of dopamine metabolic process Source: UniProtKB
Regulation of dopamine secretion Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Regulation of synapse assembly Source: UniProtKB
Regulation of synaptic transmission, dopaminergic Source: UniProtKB
Response to acetylcholine Source: ARUK-UCL
Response to cocaine Source: UniProtKB
Response to ethanol Source: UniProtKB
Response to hypoxia Source: UniProtKB
Response to nicotine Source: UniProtKB
Sensory perception of pain Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Signal transduction Source: UniProtKB
Smooth muscle contraction Source: UniProtKB
Social behavior Source: UniProtKB
Synaptic transmission, cholinergic Source: UniProtKB
Synaptic transmission involved in micturition Source: UniProtKB
Vestibulocochlear nerve development Source: UniProtKB
Visual learning Source: UniProtKB
Visual perception Source: UniProtKB
Cellular Location
Postsynaptic cell membrane; Cell membrane
Involvement in disease
Epilepsy, nocturnal frontal lobe, 3 (ENFL3): An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
Topology
Extracellular: 26-233
Helical: 234-258
Cytoplasmic: 259-265
Helical: 266-284
Extracellular: 285-299
Helical: 300-321
Cytoplasmic: 322-458
Helical: 459-478
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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