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Mouse Anti-CIAPIN1 Recombinant Antibody (CBXC-2032) (CBMAB-C5444-CQ)

This product is a mouse antibody that recognizes CIAPIN1. The antibody CBXC-2032 can be used for immunoassay techniques such as: WB, IHC.
See all CIAPIN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2032
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Recombinant protein corresponding to amino acids 97-312 of human CIAPIN1(NP_064709) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cytokine induced apoptosis inhibitor 1
Introduction
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Cytokine Induced Apoptosis Inhibitor 1; Fe-S Cluster Assembly Protein DRE2 Homolog; Cytokine-Induced Apoptosis Inhibitor 1; Predicted Protein Of HQ0915; Anamorsin; PRO0915; DRE2;
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212).

NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity).

Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Hemopoiesis Source: UniProtKB-UniRule
Iron-sulfur cluster assembly Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus; Mitochondrion intermembrane space

Han, J. H., Heo, K. S., & Myung, C. S. (2021). Cytokine‐induced apoptosis inhibitor 1 (CIAPIN1) accelerates vascular remodelling via p53 and JAK2‐STAT3 regulation in vascular smooth muscle cells. British Journal of Pharmacology, 178(22), 4533-4551.

Truong, S. D. A., Tummanatsakun, D., Proungvitaya, T., Limpaiboon, T., Wongwattanakul, M., Chua-on, D., ... & Proungvitaya, S. (2021). Serum Levels of Cytokine-Induced Apoptosis Inhibitor 1 (CIAPIN1) as a Potential Prognostic Biomarker of Cholangiocarcinoma. Diagnostics, 11(6), 1054.

Yeo, H. J., Shin, M. J., Kim, D. W., Kwon, H. Y., Eum, W. S., & Choi, S. Y. (2021). Tat-CIAPIN1 protein prevents against cytokine-induced cytotoxicity in pancreatic RINm5F β-cells. BMB reports, 54(9), 458.

Wang, J., Zhou, Y., Ma, L., Cao, S., Gao, W., Xiong, Q., ... & Yang, L. (2019). CIAPIN1 targeted NHE1 and ERK1/2 to suppress NSCLC cells’ metastasis and predicted good prognosis in NSCLC patients receiving pulmonectomy. Oxidative medicine and cellular longevity, 2019.

Yeo, H. J., Shin, M. J., You, J. H., Kim, J. S., Kim, M. Y., Kim, D. W., ... & Choi, S. Y. (2019). Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS− and TPA-induced damages. BMB reports, 52(12), 695.

Yeo, H. J., Shin, M. J., Yeo, E. J., Choi, Y. J., Kim, D. W., Kim, D. S., ... & Choi, S. Y. (2019). Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways. Free Radical Biology and Medicine, 135, 68-78.

Deng, Y. W., Hao, W. J., Li, Y. W., Li, Y. X., Zhao, B. C., & Lu, D. (2018). Hsa-miRNA-143-3p reverses multidrug resistance of triple-negative breast cancer by inhibiting the expression of its target protein cytokine-induced apoptosis inhibitor 1 in vivo. Journal of breast cancer, 21(3), 251-258.

Zhang, Y., Fang, J., & Ma, H. (2018). Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1. Biochemistry and Cell Biology, 96(5), 646-654.

Huang, Z., Su, G. F., Hu, W. J., Bi, X. X., Zhang, L., & Wan, G. (2017). The study on expression of CIAPIN1 interfering hepatocellular carcinoma cell proliferation and its mechanisms. Eur Rev Med Pharmacol Sci, 21(13), 3054-3060.

Wang, J. H., Wang, X. W., Qu, D., Sun, J. W., Guo, F. X., & Lu, D. (2017). Upregulation of microRNA-143 reverses drug resistance in human breast cancer cells via inhibition of cytokine-induced apoptosis inhibitor 1. Oncology letters, 13(6), 4695-4700.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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