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Mouse Anti-CIZ1 Antibody (V2-4483) (CBMAB-0231-YC)

Provided herein are mouse monoclonal antibodies against Human CIZ1. The antibody clone 1A2 can be used for immunoassay techniques, such as IP and MA.
See all CIZ1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-4483
Antibody Isotype
IgG2c
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2c
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CIZ1
Introduction
CIZ1 (CDKN1A interacting zinc finger protein 1) is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. CIZ1 may regulate the cellular localization of CIP1. An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage.
Entrez Gene ID
25792
UniProt ID
Q9ULV3
Alternative Names
NP94; LSFR1; ZNF356
Function
May regulate the subcellular localization of CIP/WAF1.
Cellular Location
Nucleus
Involvement in disease
Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.

Han, J., Xu, G., Dong, Q., Jing, G., Liu, Q., & Liu, J. (2022). Elevated expression of CDKN1A-interacting zinc finger protein 1 in intimal hyperplasia after endovascular arterial injury. All Life, 15(1), 95-104.

Li, Y., Zhou, X., Liu, J., Gao, N., Yang, R., Wang, Q., ... & He, Q. (2020). Dihydroartemisinin inhibits the tumorigenesis and metastasis of breast cancer via downregulating CIZ1 expression associated with TGF-β1 signaling. Life sciences, 248, 117454.

Chen, Y. R., Wu, Y. S., Wang, W. S., Zhang, J. S., & Wu, Q. G. (2020). Upregulation of lncRNA DANCR functions as an oncogenic role in non-small lung cancer by regulating miR-214-5p/CIZ1 axis. Eur Rev Med Pharmacol Sci, 24(5), 2539-2547.

Thacker, U., Pauzaite, T., Tollitt, J., Twardowska, M., Harrison, C., Dowle, A., ... & Copeland, N. A. (2020). Identification of DHX9 as a cell cycle regulated nucleolar recruitment factor for CIZ1. Scientific reports, 10(1), 1-13.

Chen, X., Wang, P., Wang, S., Li, J., Ou, T., & Zeng, X. (2019). CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis. Gene, 719, 143946.

Wang, Y., Li, X., Zhang, J., Liu, Q., Gao, P., Li, D., ... & Liu, J. (2019). CIZ1 Expression Is Upregulated in Hemangioma of the Tongue. Pathology & Oncology Research, 25(4), 1653-1658.

Zhou, X., Liu, Q., Wada, Y., Liao, L., & Liu, J. (2018). CDKN1A‑interacting zinc finger protein 1 is a novel biomarker for lung squamous cell carcinoma. Oncology letters, 15(1), 183-188.

Khan, M. M., Xiao, J., Patel, D., & LeDoux, M. S. (2018). DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice. Neurobiology of aging, 62, 180-190.

Sunwoo, H., Colognori, D., Froberg, J. E., Jeon, Y., & Lee, J. T. (2017). Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1). Proceedings of the National Academy of Sciences, 114(40), 10654-10659.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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