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Mouse Anti-CLDN11 Recombinant Antibody (398205) (CBMAB-C1070-LY)

This product is antibody recognizes CLDN11. The antibody 398205 immunoassay techniques such as: FC, CyTOF.
See all CLDN11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
398205
Antibody Isotype
IgG2b
Application
FC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Claudin 11
Introduction
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
Entrez Gene ID
5010
UniProt ID
O75508
Alternative Names
Claudin 11; Oligodendrocyte Transmembrane Protein; Oligodendrocyte-Specific Protein; OTM; OSP; Claudin-11;
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Axon ensheathment Source: Ensembl
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Spermatogenesis Source: Ensembl
Tight junction assembly Source: ARUK-UCL
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1
Helical: 2-22
Extracellular: 23-82
Helical: 83-103
Cytoplasmic: 104-122
Helical: 123-143
Extracellular: 144-157
Helical: 158-178
Cytoplasmic: 179-207

Pörtner, C., Rode, K., Hollenbach, J., Thiemeyer, H., Beineke, A., Günzel-Apel, A. R., & Brehm, R. (2020). Expression of claudin-11 in canine prepubertal testes, and in canine adult testes showing normal spermatogenesis, impaired spermatogenesis, or testicular neoplasia. Theriogenology, 148, 122-131.

Kato, T., Mizuno, K., Nishio, H., Moritoki, Y., Kamisawa, H., Kurokawa, S., ... & Yasui, T. (2020). Disorganization of claudin‐11 and dysfunction of the blood‐testis barrier during puberty in a cryptorchid rat model. Andrology, 8(5), 1398-1408.

Li, C. F., Chen, J. Y., Ho, Y. H., Hsu, W. H., Wu, L. C., Lan, H. Y., ... & Yang, M. H. (2019). Snail-induced claudin-11 prompts collective migration for tumour progression. Nature cell biology, 21(2), 251-262.

Lindsey, R. C., Xing, W., Pourteymoor, S., Godwin, C., Gow, A., & Mohan, S. (2019). Novel role for Claudin‐11 in the regulation of osteoblasts via modulation of ADAM10‐mediated notch signaling. Journal of Bone and Mineral Research, 34(10), 1910-1922.

Horné, F., Dietze, R., Berkes, E., Oehmke, F., Tinneberg, H. R., Meinhold-Heerlein, I., & Konrad, L. (2019). Impaired localization of claudin-11 in endometriotic epithelial cells compared to endometrial cells. Reproductive Sciences, 26(9), 1181-1192.

Baek, J. M., Cheon, Y. H., Kwak, S. C., Jun, H. Y., Yoon, K. H., Lee, M. S., & Kim, J. Y. (2018). Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling. Experimental & molecular medicine, 50(4), 1-18.

Shen, Z., Cao, B., Lin, L., Zhou, C., Ye, D., Qiu, S., ... & Cui, X. (2017). The clinical signification of claudin-11 promoter hypermethylation for laryngeal squamous cell carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 23, 3635.

Li, J., Zhou, C., Ni, S., Wang, S., Ni, C., Yang, P., & Ye, M. (2017). Methylated claudin-11 associated with metastasis and poor survival of colorectal cancer. Oncotarget, 8(56), 96249.

Yang, P., Zhang, M., Liu, X., & Pu, H. (2017). MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11. Experimental and therapeutic medicine, 14(3), 2625-2632.

Nissinen, L., Siljamäki, E., Riihilä, P., Piipponen, M., Farshchian, M., Kivisaari, A., ... & Kähäri, V. M. (2017). Expression of claudin‐11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ. Experimental dermatology, 26(9), 771-777.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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