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Mouse Anti-CLDN15 Recombinant Antibody (CBYY-C3168) (CBMAB-C4611-YY)

This product is mouse antibody that recognizes CLDN15. The antibody CBYY-C3168 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB
See all CLDN15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3168
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence derived from the C-terminus of human Claudin-15
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
0.5 mg/mL
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Claudin 15
Entrez Gene ID
24146
UniProt ID
P56746
Alternative Names
C5Da, C5b, CPAMD4, ECLZB, C5
Function
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na+, Li+ and K+ ions, but selects against Cl- ions. Plays an important role in paracellular Na+ transport in the intestine and in Na+ homeostasis. Required for normal Na+-dependent intestinal nutrient uptake.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Ion transport Source: UniProtKB-KW
Cellular Location
Cell membrane; Tight junction. Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.
Topology
Cytoplasmic: 1
Helical: 2-24
Extracellular: 25-74
Helical: 75-99
Cytoplasmic: 100-115
Helical: 116-140
Extracellular: 141-159
Helical: 160-182
Cytoplasmic: 183-228
PTM
Palmitoylated.

Watanabe, M., Higashi, T., Ozeki, K., Higashi, A. Y., Sugimoto, K., Mine, H., ... & Chiba, H. (2021). CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma. Scientific reports, 11(1), 1-11.

Rosenthal, R., Günzel, D., Piontek, J., Krug, S. M., Ayala‐Torres, C., Hempel, C., ... & Fromm, M. (2020). Claudin‐15 forms a water channel through the tight junction with distinct function compared to claudin‐2. Acta Physiologica, 228(1), e13334.

Tipsmark, C. K., Nielsen, A. M., Bossus, M. C., Ellis, L. V., Baun, C., Andersen, T. L., ... & Madsen, S. S. (2020). Drinking and water handling in the medaka intestine: A possible role of claudin-15 in paracellular absorption?. International journal of molecular sciences, 21(5), 1853.

Nakayama, M., Ishizuka, N., Hempstock, W., Ikari, A., & Hayashi, H. (2020). Na+-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na+ Recycling in Mouse Small Intestine. International journal of molecular sciences, 21(2), 376.

Li, J. N., Zhang, Z., Wu, G. Z., Yao, D. B., & Cui, S. S. (2020). Claudin-15 overexpression inhibits proliferation and promotes apoptosis of Schwann cells in vitro. Neural regeneration research, 15(1), 169.

Alberini, G., Benfenati, F., & Maragliano, L. (2018). Molecular dynamics simulations of ion selectivity in a claudin-15 paracellular channel. The Journal of Physical Chemistry B, 122(48), 10783-10792.

Alberini, G., Benfenati, F., & Maragliano, L. (2017). A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations. PloS one, 12(9), e0184190.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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