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Mouse Anti-CLDN3 Recombinant Antibody (CBFYC-1904) (CBMAB-C1969-FY)

This product is mouse antibody that recognizes CLDN3. The antibody CBFYC-1904 can be used for immunoassay techniques such as: IHC-P.
See all CLDN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1904
Antibody Isotype
IgG2b
Application
IHC-P

Basic Information

Immunogen
Full-length human recombinant protein of human CLDN3 (NP_001297) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Claudin 3
Introduction
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.
Entrez Gene ID
UniProt ID
Alternative Names
Claudin 3; Clostridium Perfringens Enterotoxin Receptor 2; CPE-Receptor 2; Ventral Prostate.1-Like Protein; Claudin-3; CPE-R 2; C7orf1
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Actin cytoskeleton reorganization Source: ARUK-UCL
Bicellular tight junction assembly Source: UniProtKB
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: Ensembl
Cell adhesion Source: GO_Central
Cell junction maintenance Source: ARUK-UCL
Epithelial cell morphogenesis Source: UniProtKB
Establishment of endothelial blood-brain barrier Source: ARUK-UCL
Maintenance of blood-brain barrier Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ARUK-UCL
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of wound healing Source: ARUK-UCL
Positive regulation of bicellular tight junction assembly Source: ARUK-UCL
Positive regulation of cell junction assembly Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of metallopeptidase activity Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Positive regulation of wound healing Source: ARUK-UCL
Regulation of cell morphogenesis Source: ARUK-UCL
Regulation of membrane permeability Source: ARUK-UCL
Regulation of transepithelial transport Source: ARUK-UCL
Response to ethanol Source: Ensembl
Response to hypoxia Source: UniProtKB
Cellular Location
Cell membrane; Tight junction
Involvement in disease
CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Topology
Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-80
Helical: 81-101
Cytoplasmic: 102-115
Helical: 116-136
Extracellular: 137-159
Helical: 160-180
Cytoplasmic: 181-220

Feng, J., Xu, Y., Wei, Z., Xia, Y., Zhang, H., Shen, C., ... & Fang, Y. (2022). Capsaicin inhibits migration and invasion via inhibiting epithelial-mesenchymal transition in esophageal squamous cell carcinoma by up-regulation of claudin-3 expression. Journal of Functional Foods, 89, 104934.

Anwer, S., Branchard, E., Dan, Q., Dan, A., & Szaszi, K. (2021). Tumor necrosis factor-α induces claudin-3 upregulation in kidney tubular epithelial cells through NF-κB and CREB1. American Journal of Physiology-Cell Physiology, 320(4), C495-C508.

Hempel, C., Protze, J., Altun, E., Riebe, B., Piontek, A., Fromm, A., ... & Piontek, J. (2020). Assembly of tight junction strands: Claudin-10b and claudin-3 form homo-tetrameric building blocks that polymerise in a channel-independent manner. Journal of molecular biology, 432(7), 2405-2427.

Yang, H., Park, H., Lee, Y. J., Choi, J. Y., Kim, T., Rajasekaran, N., ... & Shin, Y. K. (2020). Development of human monoclonal antibody for claudin-3 overexpressing carcinoma targeting. Biomolecules, 10(1), 51.

Yuan, M., Chen, X., Sun, Y., Jiang, L., Xia, Z., Ye, K., ... & He, Q. (2020). ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression. Acta Pharmaceutica Sinica B, 10(8), 1426-1439.

Danzinger, S., Tan, Y. Y., Rudas, M., Kastner, M. T., Weingartshofer, S., Muhr, D., ... & kConFab Investigators. (2018). Differential claudin 3 and EGFR expression predicts BRCA1 mutation in triple-negative breast cancer. Cancer investigation, 36(7), 378-388.

Che, J., Yue, D., Zhang, B., Zhang, H., Huo, Y., Gao, L., ... & Cao, B. (2018). Claudin-3 inhibits lung squamous cell carcinoma cell epithelial-mesenchymal transition and invasion via suppression of the Wnt/β-catenin signaling pathway. International journal of medical sciences, 15(4), 339.

Yamaga, K., Murota, H., Tamura, A., Miyata, H., Ohmi, M., Kikuta, J., ... & Katayama, I. (2018). Claudin-3 loss causes leakage of sweat from the sweat gland to contribute to the pathogenesis of atopic dermatitis. Journal of Investigative Dermatology, 138(6), 1279-1287.

Zhang, L., Wang, Y., Zhang, B., Zhang, H., Zhou, M., Wei, M., ... & Wang, C. (2017). Claudin-3 expression increases the malignant potential of lung adenocarcinoma cells: role of epidermal growth factor receptor activation. Oncotarget, 8(14), 23033.

Worst, T. S., Von Hardenberg, J., Gross, J. C., Erben, P., Schnölzer, M., Hausser, I., ... & Boutros, M. (2017). Database-augmented mass spectrometry analysis of exosomes identifies claudin 3 as a putative prostate cancer biomarker. Molecular & Cellular Proteomics, 16(6), 998-1008.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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