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Mouse Anti-CLDN4 Recombinant Antibody (CBCNC-190) (CBMAB-C2433-CN)

This product is a Mouse antibody that recognizes CLDN4. The antibody CBCNC-190 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all CLDN4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-190
Antibody Isotype
IgG1
Application
IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.1% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
Claudin 4
Introduction
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Entrez Gene ID
1364
UniProt ID
O14493
Alternative Names
Claudin 4; Williams-Beuren Syndrome Chromosomal Region 8 Protein; Clostridium Perfringens Enterotoxin Receptor 1; CPE-Receptor; CPETR1; WBSCR8; CPE-R;
Function
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Chloride transport Source: UniProtKB-KW
Circadian rhythm Source: Ensembl
Establishment of skin barrier Source: UniProtKB
Female pregnancy Source: Ensembl
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of metallopeptidase activity Source: ARUK-UCL
Positive regulation of wound healing Source: ARUK-UCL
Regulation of cell morphogenesis Source: ARUK-UCL
Renal absorption Source: UniProtKB
Response to progesterone Source: Ensembl
Cellular Location
Cell membrane; Tight junction. CLDN4 is required for tight junction localization in the kidney.
Involvement in disease
CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-117
Helical: 118-138
Extracellular: 139-160
Helical: 161-181
Cytoplasmic: 182-209
PTM
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.

Li, H., Neelankal John, A., Nagatake, T., Hamazaki, Y., & Jiang, F. X. (2020). Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets. FEBS open bio, 10(1), 28-40.

Rambabu, M., & Jayanthi, S. (2020). Screening approaches against claudin-4 focusing on therapeutics through molecular docking and the analysis of their relative dynamics: a theoretical approach. Journal of Receptors and Signal Transduction, 40(5), 436-441.

Luo, Y., Kishi, S., Sasaki, T., Ohmori, H., Fujiwara‐Tani, R., Mori, S., ... & Kuniyasu, H. (2020). Targeting claudin‐4 enhances chemosensitivity in breast cancer. Cancer science, 111(5), 1840.

Nakashima, C., Yamamoto, K., Kishi, S., Sasaki, T., Ohmori, H., Fujiwara-Tani, R., ... & Kuniyasu, H. (2020). Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas. Oncotarget, 11(4), 309.

Owari, T., Sasaki, T., Fujii, K., Fujiwara-Tani, R., Kishi, S., Mori, S., ... & Kuniyasu, H. (2020). Role of Nuclear Claudin-4 in Renal Cell Carcinoma. International Journal of Molecular Sciences, 21(21), 8340.

Ding, G., Liu, J., Shao, Q., Wang, B., Feng, J., Li, Y., ... & Xiao, Y. (2020). Porcine reproductive and respiratory syndrome virus structural protein GP3 regulates claudin 4 to facilitate the early stages of infection. Journal of Virology, 94(20), e00124-20.

Nishiguchi, Y., Fujiwara-Tani, R., Sasaki, T., Luo, Y., Ohmori, H., Kishi, S., ... & Kuniyasu, H. (2019). Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer. Oncotarget, 10(22), 2189.

Rambabu, M., & Jayanthi, S. (2019). Virtual screening of National Cancer Institute database for claudin‐4 inhibitors: Synthesis, biological evaluation, and molecular dynamics studies. Journal of cellular biochemistry, 120(5), 8588-8600.

Sasaki, T., Fujiwara‐Tani, R., Kishi, S., Mori, S., Luo, Y., Ohmori, H., ... & Kuniyasu, H. (2019). Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas. Cancer medicine, 8(15), 6700-6708.

Fujiwara-Tani, R., Sasaki, T., Luo, Y. I., Goto, K., Kawahara, I., Nishiguchi, Y., ... & Kuniyasu, H. (2018). Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer. Oncotarget, 9(100), 37367.

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For research use only. Not intended for any clinical use.

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