Rat Anti-CLDN9 Recombinant Antibody (14A9) (CBMAB-C2988-LY)

This product is antibody recognizes CLDN9. The antibody 14A9 immunoassay techniques such as: ELISA, FC.
See all CLDN9 antibodies

Datasheet

Summary

Host Animal

Rat

Specificity

Human

Clone

14A9

Antibody Isotype

IgG2b

Application

ELISA, FC

Basic Information

Immunogen

Genetic immunization with cDNA encoding human Claudin 9

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Claudin 9

Introduction

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010]

Entrez Gene ID

9080

UniProt ID

O95484

Alternative Names

Claudin 9; Claudin-9;

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

Biological Process

Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central

Cellular Location

Cell membrane; Tight junction

Topology

Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-116
Helical: 117-137
Extracellular: 138-159
Helical: 160-180
Cytoplasmic: 181-217

References

Hernández-Nava, E., Montaño, L. F., & Rendon-Huerta, E. P. (2021). Transcriptional and Epigenetic Bioinformatic Analysis of Claudin-9 Regulation in Gastric Cancer. Journal of Oncology, 2021.

Higashi, A. Y., Higashi, T., Furuse, K., Ozeki, K., Furuse, M., & Chiba, H. (2021). Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Scientific reports, 11(1), 1-14.

Ramzan, M., Philippe, C., Belyantseva, I. A., Nakano, Y., Fenollar‐Ferrer, C., Tona, R., ... & Naz, S. (2021). Variants of human CLDN9 cause mild to profound hearing loss. Human mutation, 42(10), 1321-1335.

Liu, H., Wang, M., Liang, N., & Guan, L. (2019). Claudin-9 enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling. The Turkish Journal of Gastroenterology, 30(8), 722.

Vecchio, A. J., & Stroud, R. M. (2019). Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proceedings of the National Academy of Sciences, 116(36), 17817-17824.

Sineni, C. J., Yildirim-Baylan, M., Guo, S., Camarena, V., Wang, G., Tokgoz-Yilmaz, S., ... & Tekin, M. (2019). A truncating CLDN9 variant is associated with autosomal recessive nonsyndromic hearing loss. Human genetics, 138(10), 1071-1075.

Gon, Y., Maruoka, S., Kishi, H., Kozu, Y., Kazumichi, K., Nomura, Y., ... & Hashimoto, S. (2017). NDRG1 is important to maintain the integrity of airway epithelial barrier through claudin‐9 expression. Cell biology international, 41(7), 716-725.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CLDN9 Recombinant Antibody (CBWJC-2775)

Rat Anti-CLDN9 Recombinant Antibody (YD4E9)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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