Sign in or Register   Sign in or Register
  |  

Mouse Anti-CLEC5A Recombinant Antibody (283834) (CBMAB-C4530-LY)

This product is antibody recognizes CLEC5A. The antibody 283834 immunoassay techniques such as: IHC-F, WB.
See all CLEC5A antibodies
Published Data
Fig.1 Immunofluorescent analysis of CLEC5A in lungs of mice exposed to FA.
...View More
Fig.2 CLEC5A expression on lung macrophage of never smokers (NS) and current smoker.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
283834
Antibody Isotype
IgG2b
Application
IHC-F, WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human MDL-1/CLEC5A Tyr26-Lys188
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
5% trehalose
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-Type Lectin Domain Containing 5A
Introduction
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
23601
UniProt ID
Q9NY25
Alternative Names
C-Type Lectin Domain Containing 5A; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 5; C-Type Lectin Domain Family 5 Member A; C-Type Lectin Superfamily Member 5; CLECSF5; MDL-1;
Function
Functions as a positive regulator of osteoclastogenesis (By similarity).

Cell surface receptor that signals via TYROBP (PubMed:10449773).

Regulates inflammatory responses (By similarity).

(Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123).

The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526).

This interaction does not result in viral entry, but stimulates proinflammatory cytokine release (PubMed:18496526).
Biological Process
Cellular defense response Source: ProtInc
Innate immune response Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neutrophil degranulation Source: Reactome
Osteoblast development Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-4
Helical: 5-27
Extracellular: 28-188
PTM
N-glycosylated. Contains sialic acid residues.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CLEC5A Recombinant Antibody (283834)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare