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Rabbit Anti-CLGN Recombinant Antibody (EPR11832-11) (CBMAB-1384-CN)

This product is a rabbit antibody that recognizes CLGN of human. The antibody EPR11832-11 can be used for immunoassay techniques such as: WB, IHC-P, IF, IP, FC.
See all CLGN antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Chimpanzee
Clone
EPR11832-11
Antibody Isotype
IgG
Application
WB, IHC-P, IF, IP, FC

Basic Information

Immunogen
Recombinant fragment within Human Calmegin.
Specificity
Human, Mouse, Rat, Chimpanzee
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calmegin
Introduction
Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertilityThis protein functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. It is required for normal sperm migration from the uterus into the oviduct.
Entrez Gene ID
Human1047
Mouse12745
Rat685504
Chimpanzee461501
UniProt ID
HumanO14967
MouseP52194
RatD3ZFS2
ChimpanzeeG2HF63
Alternative Names
calmegin; testis tissue sperm-binding protein Li 79P
Function
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: GO_Central
Protein-containing complex assembly Source: Ensembl
Protein folding Source: GO_Central
Single fertilization Source: ProtInc
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 20-471
Helical: 472-492
Cytoplasmic: 493-610
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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