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Mouse Anti-CLIC5 Recombinant Antibody (CBFYC-0328) (CBMAB-C0364-FY)

This product is mouse antibody that recognizes CLIC5. The antibody CBFYC-0328 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all CLIC5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0328
Antibody Isotype
IgG3, k
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chloride intracellular channel 5
Introduction
This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
53405
UniProt ID
Q9NZA1
Alternative Names
Chloride Intracellular Channel 5; Chloride Intracellular Channel Protein 5; DFNB102; DFNB103; MSTP130; MST130
Function
Required for normal hearing (PubMed:24781754).

It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity).

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315).

Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity).
Biological Process
Chloride transport Source: UniProtKB
Female pregnancy Source: ProtInc
Glutathione metabolic process Source: InterPro
Regulation of ion transmembrane transport Source: UniProtKB-KW
Response to stimulus Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Visual perception Source: UniProtKB-KW
Cellular Location
Isoform 1: Cytoplasm; Cytoskeleton; Apical cell membrane; Cell cortex; Membrane. Associates with the cortical actin cytoskeleton (PubMed:10793131, PubMed:15184393). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (By similarity). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (PubMed:20335315). May localize to the centrosome in lens epithelial cells (By similarity). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
Isoform 2: Golgi apparatus; Centrosome. Colocalizes with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome.
Involvement in disease
Deafness, autosomal recessive, 103 (DFNB103):
A form of sensorineural deafness with onset in early childhood. Hearing impairment progresses from mild to severe or even profound before the second decade, and is accompanied by vestibular areflexia.
Topology
Helical: 193-213
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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