Mouse Anti-CLMP (AA 1-233) Recombinant Antibody (CBFYC-1949) (CBMAB-C2015-FY)

This product is mouse antibody that recognizes CLMP. The antibody CBFYC-1949 can be used for immunoassay techniques such as: ELISA.
See all CLMP antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYC-1949

Application

ELISA

Basic Information

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-233

Target

Full Name

CXADR Like Membrane Protein

Introduction

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome.

Entrez Gene ID

79827

UniProt ID

Q9H6B4

Alternative Names

CXADR Like Membrane Protein; Coxsackie-And Adenovirus Receptor-Like Membrane Protein; Adipocyte-Specific Adhesion Molecule; Adipocyte Adhesion Molecule; CAR-Like Membrane Protein; ACAM

Function

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.

Biological Process

Digestive tract development Source: UniProtKB

Cellular Location

Cell membrane; Tight junction

Involvement in disease

Congenital short bowel syndrome (CSBS):
A disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life.

Topology

Extracellular: 19-235
Helical: 236-256
Cytoplasmic: 257-373

References

Mamoor, S. (2021). Differential expression of CXADR-like membrane protein in cancers of the breast.

Han, X., Zhao, Z. A., Yan, S., Lei, W., Wu, H., Lu, X. A., ... & Hu, S. (2020). CXADR‐like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction. Journal of cellular and molecular medicine, 24(23), 13775-13788.

Chuang, Y. H., Fan, W. L., Chu, Y. D., Liang, K. H., Yeh, Y. M., Chen, C. C., ... & Lai, M. W. (2020). Whole-Exome Sequencing Identified Novel CLMP Mutations in a Family With Congenital Short Bowel Syndrome Presenting Differently in Two Probands. Frontiers in Genetics, 11, 1610.

Gharesouran, J., Esfahani, B. S., Valilou, S. F., Moradi, M., Mousavi, M. H., & Rezazadeh, M. (2019). First report of congenital short bowel syndrome in an Iranian patient caused by a mutation in the CLMP gene. Journal of pediatric genetics, 8(02), 073-080.

Langhorst, H., Jüttner, R., Groneberg, D., Mohtashamdolatshahi, A., Pelz, L., Purfürst, B., ... & Rathjen, F. G. (2018). The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice. Disease models & mechanisms, 11(2), dmm032128.

Nusrat, A., Parkos, C. A., & Luissint, A. C. (2018). CLMP-mediated regulation of intestinal homeostasis in IBD. University of Michigan Ann Arbor United States.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-CLMP (AA 1-233) Recombinant Antibody (CBFYC-1949)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-CLMP Recombinant Antibody (3E1)

Mouse Anti-CLMP Recombinant Antibody (1H2B5D10)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote

Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: