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Mouse Anti-CLNS1A Recombinant Antibody (8C78) (CBMAB-C2482-CN)

This product is a Mouse antibody that recognizes CLNS1A. The antibody 8C78 can be used for immunoassay techniques such as: WB.
See all CLNS1A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
8C78
Application
WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human CLNS1A
Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL

Target

Full Name
Chloride Nucleotide-Sensitive Channel 1A
Introduction
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Entrez Gene ID
Human1207
Mouse12729
Rat65160
UniProt ID
HumanP54105
MouseQ61189
RatQ04753
Alternative Names
Chloride Nucleotide-Sensitive Channel 1A; Chloride Conductance Regulatory Protein ICln; Chloride Channel, Nucleotide Sensitive 1A; Chloride Ion Current Inducer Protein; Methylosome Subunit PICln; Reticulocyte PICln; I(Cln);
Function
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161).

Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
Biological Process
Cell volume homeostasis Source: InterPro
Chloride transport Source: InterPro
Spliceosomal snRNP assembly Source: UniProtKB
Cellular Location
Cytoskeleton; Nucleus; Cytosol. A small fraction is also associated with the cytoskeleton (PubMed:18984161).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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