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Rabbit Anti-CLSTN1 Recombinant Antibody (EPR2963) (CBMAB-1388-CN)

This product is a rabbit antibody that recognizes CLSTN1 of human. The antibody EPR2963 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all CLSTN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EPR2963
Antibody Isotype
IgG
Application
IF, IHC-P, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues at the C terminus of Human CLSTN1
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calsyntenin 1
Introduction
This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. The protein induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport.
Entrez Gene ID
Human22883
Mouse65945
UniProt ID
HumanO94985
MouseQ9EPL2
Alternative Names
CST-1; CSTN1; CDHR12; PIK3CD; ALC-ALPHA; XB31alpha; alcalpha1; alcalpha2
Function
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
Biological Process
Cell adhesion Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Neurotransmitter receptor transport to postsynaptic membrane Source: Ensembl
Positive regulation of synapse assembly Source: GO_Central
Positive regulation of synaptic transmission Source: GO_Central
Regulation of cell growth Source: Ensembl
Regulation of synapse maturation Source: Ensembl
Vesicle-mediated transport in synapse Source: Ensembl
Cellular Location
Golgi apparatus membrane; Postsynaptic cell membrane; Endoplasmic reticulum membrane; Nucleus; Neuron projection. Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1.
Topology
Extracellular: 29-859
Helical: 860-880
Cytoplasmic: 881-981
PTM
Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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