Mouse Anti-CMAS Recombinant Antibody (CBXC-1548) (CBMAB-C5548-CQ)

This product is a mouse antibody that recognizes CMAS. The antibody CBXC-1548 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all CMAS antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-1548

Antibody Isotype

IgG

Application

ELISA, IF, WB

Basic Information

Immunogen

CMAS (NP_061156, 164aa-263aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

cytidine monophosphate N-acetylneuraminic acid synthetase

Introduction

This gene encodes an enzyme that converts N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc). This process is important in the formation of sialylated glycoprotein and glycolipids. This modification plays a role in cell-cell communications and immune responses. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

55907

UniProt ID

Q8NFW8

Alternative Names

Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase; N-Acylneuraminate Cytidylyltransferase; CMP-N-Acetylneuraminic Acid Synthase; CMP-Neu5Ac Synthetase; CMP-NeuNAc Synthase; EC 2.7.7.43;

Function

Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).

Biological Process

N-acetylneuraminate metabolic process Source: UniProtKB-UniPathway

Cellular Location

Nucleus

References

Urbanek, K., Sutherland, D. M., Orchard, R. C., Wilen, C. B., Knowlton, J. J., Aravamudhan, P., ... & Dermody, T. S. (2020). Cytidine monophosphate N-acetylneuraminic acid synthetase and solute carrier family 35 member A1 are required for reovirus binding and infection. Journal of virology, 95(2), e01571-20.

Qu, R., Sang, Q., Wang, X., Xu, Y., Chen, B., Mu, J., ... & Wang, L. (2020). A homozygous mutation in CMAS causes autosomal recessive intellectual disability in a Kazakh family. Annals of Human Genetics, 84(1), 46-53.

O’Day, E. M., Idos, G. E., Hill, C., Chen, J. W., & Wagner, G. (2018). Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells. OncoTargets and therapy, 11, 6827.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CMAS Recombinant Antibody (2E1)

Mouse Anti-CMAS Recombinant Antibody (5A2)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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