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Mouse Anti-CMTM4 (AA 173-234) Recombinant Antibody (CBFYC-1977) (CBMAB-C2043-FY)

This product is mouse antibody that recognizes CMTM4. The antibody CBFYC-1977 can be used for immunoassay techniques such as: ELISA, WB.
See all CMTM4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1977
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Immunogen
CMTM4 (NP_848933, 173 a.a.-234 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: QKWRVSVRQQ STNDYIRART ESRDVDSRPE IQRLDTFSYS TNVTVRKKSP TNLLSLNHWQ LA
Specificity
Human
Antibody Isotype
IgG1, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 173-234

Target

Full Name
CKLF-like MARVEL transmembrane domain containing 4
Introduction
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
146223
UniProt ID
Q8IZR5
Alternative Names
CKLF Like MARVEL Transmembrane Domain Containing 4; Chemokine-Like Factor Superfamily Member 4; Chemokine-Like Factor Super Family 4; CKLFSF4; CKLF-Like MARVEL Transmembrane Domain-Containing Protein 4; CKLF-Like MARVEL Transmembrane Domain Containing 4; Chemokine-Like Factor Superfamily 4
Function
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Cellular Location
Membrane

Chui, N. N. Q., Cheu, J. W. S., Yuen, V. W. H., Chiu, D. K. C., Goh, C. C., Lee, D., ... & Wong, C. C. L. (2022). Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell–Mediated Antitumor Immunity Through PD‐L1. Hepatology communications, 6(1), 178-193.

Takeuchi, H., Konnai, S., Maekawa, N., Minato, E., Ichikawa, Y., Kobayashi, A., ... & Ohashi, K. (2020). Expression analysis of canine CMTM6 and CMTM4 as potential regulators of the PD-L1 protein in canine cancers. Frontiers in veterinary science, 7, 330.

Chrifi, I., Louzao-Martinez, L., Brandt, M. M., Van Dijk, C. G., Bürgisser, P. E., Zhu, C., ... & Cheng, C. (2019). CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions. Angiogenesis, 22(1), 75-93.

Xue, H., Li, T., Wang, P., Mo, X., Zhang, H., Ding, S., ... & Han, W. (2019). CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer. Acta Biochimica et Biophysica Sinica, 51(9), 915-924.

Liu, F., Liu, X., Liu, X., Li, T., Zhu, P., Liu, Z., ... & Han, W. (2019). Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male Fertility*[S]. Molecular & Cellular Proteomics, 18(6), 1070-1084.

Bei, C., Zhang, Y., Wei, R., Zhu, X., Wang, Z., Zeng, W., ... & Tan, S. (2017). Clinical significance of CMTM4 expression in hepatocellular carcinoma. OncoTargets and therapy, 10, 5439.

Mezzadra, R., Sun, C., Jae, L. T., Gomez-Eerland, R., De Vries, E., Wu, W., ... & Schumacher, T. N. (2017). Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 549(7670), 106-110.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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