Mouse Anti-CMTM5 Recombinant Antibody (2B10) (CBMAB-C0820-LY)

This product is antibody recognizes CMTM5. The antibody 2B10 immunoassay techniques such as: ELISA.
See all CMTM5 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2B10

Antibody Isotype

IgG3

Application

ELISA

Basic Information

Immunogen

Recombinant protein corresponding to aa1-156 from full-length human CMTM5 with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG3

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

CKLF Like MARVEL Transmembrane Domain Containing 5

Introduction

This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Entrez Gene ID

116173

UniProt ID

Q96DZ9

Alternative Names

CKLF Like MARVEL Transmembrane Domain Containing 5; Chemokine-Like Factor Superfamily Member 5; Chemokine-Like Factor Super Family 5; CKLFSF5; CKLF-Like MARVEL Transmembrane Domain-Containing Protein 5; CKLF-Like MARVEL Transmembrane Domain Containing 5;

Biological Process

Chemotaxis Source: UniProtKB-KW
Negative regulation of myoblast differentiation Source: Ensembl

Cellular Location

Membrane

References

Li, L., Hu, Y., Chen, D., Zhu, J., Bao, W., Xu, X., ... & Feng, R. (2022). CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway. Molecular Medicine Reports, 25(1), 1-10.

Yuan, Y., Sheng, Z., Liu, Z., Zhang, X., Xiao, Y., Xie, J., ... & Xu, T. (2020). CMTM5-v1 inhibits cell proliferation and migration by downregulating oncogenic EGFR signaling in prostate cancer cells. Journal of Cancer, 11(13), 3762.

Zhou, J., Lei, J., Wang, J., Lian, C. L., Hua, L., He, Z. Y., & Wu, S. G. (2020). Bioinformatics-based discovery of CKLF-Like MARVEL transmembrane member 5 as a novel biomarker for breast cancer. Frontiers in Cell and Developmental Biology, 361.

Wu, J. (2020). CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma. Cancer Biomarkers, 29(1), 89-99.

Zhang, J. W., Liu, T. F., Chen, X. H., Liang, W. Y., Feng, X. R., Wang, L., ... & Liu, M. L. (2017). Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function. Gene, 624, 56-65.

Xu, G., & Dang, C. (2017). CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling. Cancer cell international, 17(1), 1-10.

Cai, B., Xiao, Y., Li, Y., & Zheng, S. (2017). CMTM5 inhibits renal cancer cell growth through inducing cell-cycle arrest and apoptosis. Oncology letters, 14(2), 1536-1542.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CMTM5 (AA 1-156) Recombinant Antibody (CBFYC-1978)

Mouse Anti-CMTM5 Recombinant Antibody (CBXC-0484)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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