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Mouse Anti-CNOT4 (AA 190-455) Recombinant Antibody (CBFYC-1997) (CBMAB-C2063-FY)

This product is mouse antibody that recognizes CNOT4. The antibody CBFYC-1997 can be used for immunoassay techniques such as: IHC-P, WB.
See all CNOT4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1997
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 190-455 of human CNOT4 (NP_037448) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 190-455

Target

Full Name
CCR4-NOT Transcription Complex Subunit 4
Introduction
The protein CNOT4 possesses an N-terminal RING finger domain that acts as an E3 ubiquitin ligase and specifically interacts with UbcH5B, a ubiquitin-conjugating enzyme.
Entrez Gene ID
4850
UniProt ID
O95628
Alternative Names
CCR4-NOT Transcription Complex Subunit 4; Potential Transcriptional Repressor NOT4Hp; RING-Type E3 Ubiquitin Transferase CNOT4; E3 Ubiquitin-Protein Ligase CNOT4; CCR4-Associated Factor 4; NOT4
Function
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292).

Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038).

Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).

Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391).

As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391).
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
Protein autoubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of megakaryocyte differentiation Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
PTM
Autoubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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