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Mouse Anti-Cnp Recombinant Antibody (CBMAB-0648-LY)

This product is mouse antibody recognizes Cnp of rat. The antibody immunoassay techniques such as: IF, IHC, WB.
See all Cnp antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Hamster, Mouse
Antibody Isotype
IgG1
Application
IF, IHC, WB

Basic Information

Specificity
Rat, Hamster, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
2',3'-Cyclic Nucleotide 3' Phosphodiesterase
Introduction
microtubule-binding protein that promotes microtubule assembly and may regulate cellular distribution of microtubules. May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Entrez Gene ID
Hamster100753220
Mouse12799
Rat25275
UniProt ID
HamsterA0A1U7R749
MouseP16330
RatP13233
Function
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Biological Process
Adult locomotory behavior Source: Ensembl
Aging Source: Ensembl
Axonogenesis Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Cyclic nucleotide catabolic process Source: InterPro
Forebrain development Source: Ensembl
Microtubule cytoskeleton organization Source: Ensembl
Oligodendrocyte differentiation Source: Ensembl
Regulation of mitochondrial membrane permeability Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to toxic substance Source: Ensembl
Substantia nigra development Source: UniProtKB
Cellular Location
Membrane; Melanosome. Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Jo, Y. R., Kim, H. R., Jang, S. Y., Go, H., Song, M. Y., Park, D. K., ... & Park, H. T. (2021). Potential neuron‐autonomous Purkinje cell degeneration by 2′, 3′‐cyclic nucleotide 3′‐phosphodiesterase promoter/Cre‐mediated autophagy impairments. The FASEB Journal, 35(1), e21225.

Tan, K. S., Wang, D., Lu, Z., Zhang, Y., Li, S., Lin, Y., & Tan, W. (2021). CNPase, a 2’, 3’-Cyclic-nucleotide 3’-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production. International Journal of Molecular Sciences, 22(19), 10806.

Platt, D. C., Rink, J., Braich, K., McLauchlan, C. C., & Jones, M. A. (2021). 2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition by Organometallic Vanadium Complexes: A Potential New Paradigm for Studying CNS Degeneration. Brain sciences, 11(5), 588.

Duggal, Y., Kurasz, J. E., Fontaine, B. M., Marotta, N. J., Chauhan, S. S., Karls, A. C., & Weinert, E. E. (2021). Cellular Effects of 2′, 3′-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria. Journal of Bacteriology, 204(1), e00208-21.

Olga, K., Yulia, B., & Vassilios, P. (2020). The functions of mitochondrial 2′, 3′-cyclic nucleotide-3′-phosphodiesterase and prospects for its future. International Journal of Molecular Sciences, 21(9), 3217.

Unlu, I., Lu, Y., & Wang, X. (2018). The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress. Journal of Biological Chemistry, 293(50), 19365-19376.

Baburina, Y., Odinokova, I., Azarashvili, T., Akatov, V., Sotnikova, L., & Krestinina, O. (2018). Possible involvement of 2′, 3′-cyclic nucleotide-3′-phosphodiesterase in the protein phosphorylation-mediated regulation of the permeability transition pore. International Journal of Molecular Sciences, 19(11), 3499.

Fontaine, B. M., Martin, K. S., Garcia-Rodriguez, J. M., Jung, C., Briggs, L., Southwell, J. E., ... & Weinert, E. E. (2018). RNase I regulates Escherichia coli 2′, 3′-cyclic nucleotide monophosphate levels and biofilm formation. Biochemical Journal, 475(8), 1491-1506.

Baburina, Y., Odinokova, I., Azarashvili, T., Akatov, V., Lemasters, J. J., & Krestinina, O. (2017). 2′, 3′-Cyclic nucleotide 3′-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1859(1), 94-103.

Snaidero, N., Velte, C., Myllykoski, M., Raasakka, A., Ignatev, A., Werner, H. B., ... & Simons, M. (2017). Antagonistic functions of MBP and CNP establish cytosolic channels in CNS myelin. Cell reports, 18(2), 314-323.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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