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Mouse Anti-CNTFR Recombinant Antibody (CBFYC-2013) (CBMAB-C2079-FY)

This product is mouse antibody that recognizes CNTFR. The antibody CBFYC-2013 can be used for immunoassay techniques such as: WB.
See all CNTFR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2013
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human CNTF R alpha, Gln23-Pro346 (predicted)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ciliary Neurotrophic Factor Receptor
Introduction
CNTFR (Ciliary Neurotrophic Factor Receptor) is a Protein Coding gene. Diseases associated with CNTFR include Cold-Induced Sweating Syndrome and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding and ciliary neurotrophic factor receptor activity. An important paralog of this gene is IL11RA.
Entrez Gene ID
1271
UniProt ID
P26992
Alternative Names
Ciliary Neurotrophic Factor Receptor; CNTF Receptor Subunit Alpha; CNTFR-Alpha; Ciliary Neurotrophic Factor Receptor Subunit Alpha
Function
Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303).
Biological Process
Brainstem development Source: Ensembl
Ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Negative regulation of neuron apoptotic process Source: Ensembl
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: Ensembl
Sex differentiation Source: Ensembl
Signal transduction Source: ProtInc
Skeletal muscle organ development Source: Ensembl
Suckling behavior Source: Ensembl
Cellular Location
Cell membrane

Zhong, P., Zeng, G., Lei, C., Tian, G., Ouyang, S., Liu, F., & Peng, J. (2021). Ciliary neurotrophic factor overexpression protects the heart against pathological remodelling in angiotensin II-infused mice. Biochemical and Biophysical Research Communications, 547, 15-22.

Homma, H., Kobatake, N., Sekimoto, Y., Saito, M., Mochizuki, Y., Okamoto, T., ... & Kikuchi, N. (2020). Ciliary neurotrophic factor receptor rs41274853 polymorphism is associated with weightlifting performance in Japanese weightlifters. The Journal of Strength & Conditioning Research, 34(11), 3037-3041.

Jia, C., Oliver, J., Gilmer, D., Lovins, C., Rodriguez-Gil, D. J., & Hagg, T. (2020). Inhibition of focal adhesion kinase increases adult olfactory stem cell self-renewal and neuroregeneration through ciliary neurotrophic factor. Stem cell research, 49, 102061.

Wang, L., Zhang, H., & Lei, D. (2019). microRNA-146a promotes growth of acute leukemia cells by downregulating ciliary neurotrophic factor receptor and activating JAK2/STAT3 signaling. Yonsei Medical Journal, 60(10), 924-934.

Jia, C., Brown, R. W., Malone, H. M., Burgess, K. C., Gill, W. D., Keasey, M. P., & Hagg, T. (2019). Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice. Psychoneuroendocrinology, 100, 96-105.

Zheng, K., Zhang, Q., Sheng, Z., Li, Y., & Lu, H. H. (2018). Ciliary neurotrophic factor (CNTF) protects myocardial cells from oxygen glucose deprivation (OGD)/re-oxygenation via activation of Akt-Nrf2 signaling. Cellular Physiology and Biochemistry, 51(4), 1852-1862.

Ghasemi, M., Alizadeh, E., Saei Arezoumand, K., Fallahi Motlagh, B., & Zarghami, N. (2018). Ciliary neurotrophic factor (CNTF) delivery to retina: an overview of current research advancements. Artificial cells, nanomedicine, and biotechnology, 46(8), 1694-1707.

Baek, J. Y., Jeong, J. Y., Kim, K. I., Won, S. Y., Chung, Y. C., Nam, J. H., ... & Jin, B. K. (2018). Inhibition of microglia-derived oxidative stress by ciliary neurotrophic factor protects dopamine neurons in vivo from MPP+ neurotoxicity. International journal of molecular sciences, 19(11), 3543.

Li, S., Sato, K., Gordon, W. C., Sendtner, M., Bazan, N. G., & Jin, M. (2018). Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments. Journal of Biological Chemistry, 293(39), 15256-15268.

Shpak, A. A., Guekht, A. B., Druzhkova, T. A., Kozlova, K. I., & Gulyaeva, N. V. (2017). Ciliary neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract. Molecular vision, 23, 799.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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