Sign in or Register   Sign in or Register
  |  

Rabbit Anti-CNTNAP2 Recombinant Antibody (D6S1O) (CBMAB-CP0126-LY)

The product is antibody recognizes CNTNAP2. The antibody D6S1O immunoassay techniques such as: WB.
See all CNTNAP2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D6S1O
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln1040 of human Caspr2 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Contactin Associated Protein Like 2
Introduction
CNTNAP2 (Contactin Associated Protein Like 2) is a Protein Coding gene. Diseases associated with CNTNAP2 include Pitt-Hopkins-Like Syndrome 1 and Autism 15. Among its related pathways are Neuroscience and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is CNTNAP5.
Entrez Gene ID
Human26047
Mouse66797
Rat500105
UniProt ID
HumanQ9UHC6
MouseQ9CPW0
RatP97846
Alternative Names
Contactin Associated Protein Like 2; Cell Recognition Molecule Caspr2; CASPR2; Contactin-Associated Protein-Like 2; Homolog Of Drosophila Neurexin IV; KIAA0868;
Function
Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.
Biological Process
Adult behavior Source: BHF-UCL
Brain development Source: BHF-UCL
Cell adhesion Source: UniProtKB-KW
Cerebral cortex development Source: BHF-UCL
Clustering of voltage-gated potassium channels Source: BHF-UCL
Learning Source: BHF-UCL
Limbic system development Source: BHF-UCL
Neuron projection development Source: BHF-UCL
Neuron projection morphogenesis Source: UniProtKB
Neuron recognition Source: UniProtKB
Positive regulation of gap junction assembly Source: UniProtKB
Protein localization to juxtaparanode region of axon Source: BHF-UCL
Social behavior Source: BHF-UCL
Striatum development Source: BHF-UCL
Superior temporal gyrus development Source: BHF-UCL
Thalamus development Source: BHF-UCL
Transmission of nerve impulse Source: UniProtKB
Vocalization behavior Source: BHF-UCL
Vocal learning Source: BHF-UCL
Cellular Location
Membrane; Axon; Paranodal septate junction. Expressed in the juxtaparadonal region.
Involvement in disease
Autism 15 (AUTS15):
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.
Pitt-Hopkins-like syndrome 1 (PTHSL1):
A syndrome characterized by severe mental retardation and variable additional symptoms, such as impaired speech development, seizures, autistic behavior, breathing anomalies and a broad mouth, resembling Pitt-Hopkins syndrome. In contrast to patients with Pitt-Hopkins syndrome, PTHSL1 patients present with normal or only mildly to moderately delayed motor milestones.
Topology
Extracellular: 28-1262
Helical: 1263-1283
Cytoplasmic: 1284-1331

Xing, X., Wu, K., Dong, Y., Zhou, Y., Zhang, J., Jiang, F., ... & Li, J. D. (2020). Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice. Neuropharmacology, 165, 107816.

Xing, X., Zhang, J., Wu, K., Cao, B., Li, X., Jiang, F., ... & Li, J. D. (2019). Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice. Scientific reports, 9(1), 1-9.

Gu, H., Hou, F., Liu, L., Luo, X., Nkomola, P. D., Xie, X., ... & Song, R. (2018). Genetic variants in the CNTNAP2 gene are associated with gender differences among dyslexic children in China. EBioMedicine, 34, 165-170.

Toma, C., Pierce, K. D., Shaw, A. D., Heath, A., Mitchell, P. B., Schofield, P. R., & Fullerton, J. M. (2018). Comprehensive cross-disorder analyses of CNTNAP2 suggest it is unlikely to be a primary risk gene for psychiatric disorders. PLoS genetics, 14(12), e1007535.

Lauber, E., Filice, F., & Schwaller, B. (2018). Dysregulation of parvalbumin expression in the Cntnap2−/− mouse model of autism spectrum disorder. Frontiers in molecular neuroscience, 11, 262.

Gao, R., Piguel, N. H., Melendez-Zaidi, A. E., Martin-de-Saavedra, M. D., Yoon, S., Forrest, M. P., ... & Penzes, P. (2018). CNTNAP2 stabilizes interneuron dendritic arbors through CASK. Molecular psychiatry, 23(9), 1832-1850.

Bridi, M. S., Park, S. M., & Huang, S. (2017). Developmental disruption of GABAAR-meditated inhibition in Cntnap2 KO mice. ENeuro, 4(5).

Zare, S., Mashayekhi, F., & Bidabadi, E. (2017). The association of CNTNAP2 rs7794745 gene polymorphism and autism in Iranian population. Journal of Clinical Neuroscience, 39, 189-192.

Poot, M. (2017). Intragenic CNTNAP2 deletions: a bridge too far. Molecular Syndromology, 8(3), 118-130.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rabbit Anti-CNTNAP2 Recombinant Antibody (D6S1O)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare