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Mouse Anti-COL10A1 Recombinant Antibody (X-AC9) (CBMAB-C11094-LY)

The product is antibody recognizes COL10A1. The antibody X-AC9 immunoassay techniques such as: IF, IHC-F, IHC-P.
See all COL10A1 antibodies

Summary

Host Animal
Mouse
Specificity
Chicken
Clone
X-AC9
Antibody Isotype
IgG1, κ
Application
IF, IHC-F, IHC-P

Basic Information

Immunogen
Purified chicken type X collagen
Specificity
Chicken
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.2% BSA
Preservative
0.09% sodium azide
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type X Alpha 1 Chain
Introduction
COL10A1 (Collagen Type X Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL10A1 include Metaphyseal Chondrodysplasia, Schmid Type and Cartilage-Hair Hypoplasia. Among its related pathways are Integrin Pathway and ERK Signaling. An important paralog of this gene is COL8A2.
Entrez Gene ID
100858979
UniProt ID
P08125
Function
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
Biological Process
Collagen fibril organization Source: Reactome
Extracellular matrix organization Source: GO_Central
Skeletal system development Source: ProtInc
Cellular Location
Extracellular matrix
Involvement in disease
Schmid type metaphyseal chondrodysplasia (SMCD):
Dominantly inherited disorder of the osseous skeleton. The cardinal features of the phenotype are mild short stature, coxa vara and a waddling gait. Radiography usually shows sclerosis of the ribs, flaring of the metaphyses, and a wide irregular growth plate, especially of the knees. A variant form of SMCD is spondylometaphyseal dysplasia Japanese type. It is characterized by spinal involvement comprising mild platyspondyly, vertebral body abnormalities, and end-plate irregularity.
PTM
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Lv, D., Chen, D., Wang, Z., Cui, Z., Ma, J. H., Ji, S., ... & Tang, S. (2022). COL10A1 is a novel factor in the development of choroidal neovascularization. Microvascular Research, 139, 104239.

Chen, S., Wei, Y., Liu, H., Gong, Y., Zhou, Y., Yang, H., & Tang, L. (2021). Analysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics. Bioengineered, 12(1), 127-137.

Wu, H., Wang, S., Li, G., Yao, Y., Wang, N., Sun, X., ... & Xu, C. (2021). Characterization of a novel COL10A1 variant associated with Schmid‐type metaphyseal chondrodysplasia and a literature review. Molecular genetics & genomic medicine, 9(5), e1668.

Yang, W., Wu, X., & Zhou, F. (2021). Collagen Type X Alpha 1 (COL10A1) Contributes to Cell Proliferation, Migration, and Invasion by Targeting Prolyl 4-Hydroxylase Beta Polypeptide (P4HB) in Breast Cancer. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e928919-1.

Aktas, S. H., Taskin-Tok, T., Al-Khafaji, K., & Akın-Balı, D. F. (2021). A detailed understanding of the COL10A1 and SOX9 genes interaction based on potentially damaging mutations in gastric cancer using computational techniques. Journal of Biomolecular Structure and Dynamics, 1-12.

Zhang, M., Chen, H., Wang, M., Bai, F., & Wu, K. (2020). Bioinformatics analysis of prognostic significance of COL10A1 in breast cancer. Bioscience Reports, 40(2).

Zhang, X., Liang, H., Liu, W., Li, X., Zhang, W., & Shang, X. (2019). A novel sequence variant in COL10A1 causing spondylometaphyseal dysplasia accompanied with coxa valga: A case report. Medicine, 98(30).

Huang, H., Li, T., Ye, G., Zhao, L., Zhang, Z., Mo, D., ... & Liu, H. (2018). High expression of COL10A1 is associated with poor prognosis in colorectal cancer. OncoTargets and therapy, 11, 1571.

Zhang, C., Liu, J., Iqbal, F., Lu, Y., Mustafa, S., Bukhari, F., ... & Xu, S. (2018). A missense point mutation in COL10A1 identified with whole-genome deep sequencing in a 7-generation Pakistan dwarf family. Heredity, 120(1), 83-89.

ul Ain, N., Makitie, O., & Naz, S. (2018). Autosomal recessive chondrodysplasia with severe short stature caused by a biallelic COL10A1 variant. Journal of Medical Genetics, 55(6), 403-407.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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