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Mouse Anti-COL5A1 Recombinant Antibody (10B2289) (CBMAB-C2185-LY)

This product is antibody recognizes COL5A1. The antibody 10B2289 immunoassay techniques such as: ELISA, IHC.
See all COL5A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10B2289
Antibody Isotype
IgM
Application
ELISA, IHC

Basic Information

Immunogen
Purified human collagen V
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type V Alpha 1 Chain
Introduction
COL5A1 (Collagen Type V Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL5A1 include Ehlers-Danlos Syndrome, Classic Type, 1 and Ehlers-Danlos Syndrome Type 2. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and extracellular matrix structural constituent.
An important paralog of this gene is COL11A1.
Entrez Gene ID
UniProt ID
Alternative Names
Collagen Type V Alpha 1 Chain; Collagen Alpha-1(V) Chain; Collagen, Type V, Alpha 1; Alpha 1 Type V Collagen; Collagen Type V Alpha 1; EC 2.7.7.6; EC 6.1.1; EDSCL1; EDSC;
Function
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
Biological Process
Blood vessel development Source: Ensembl
Cell adhesion Source: UniProtKB
Cell migration Source: UniProtKB
Collagen biosynthetic process Source: UniProtKB
Collagen fibril organization Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Eye morphogenesis Source: UniProtKB
Heart morphogenesis Source: Ensembl
Integrin biosynthetic process Source: UniProtKB
Negative regulation of endodermal cell differentiation Source: UniProtKB
Regulation of cellular component organization Source: Ensembl
Skin development Source: UniProtKB
Supramolecular fiber organization Source: UniProtKB
Tendon development Source: Ensembl
Wound healing, spreading of epidermal cells Source: UniProtKB
Cellular Location
Extracellular matrix
Involvement in disease
Ehlers-Danlos syndrome, classic type, 1 (EDSCL1):
A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. The main features of classic Ehlers-Danlos syndrome are joint hypermobility and dislocation, and fragile, bruisable skin. EDSCL1 inheritance is autosomal dominant.
PTM
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sulfated on 40% of tyrosines.

Zhu, H., Hu, X., Feng, S., Jian, Z., Xu, X., Gu, L., & Xiong, X. (2022). The Hypoxia-Related Gene COL5A1 Is a Prognostic and Immunological Biomarker for Multiple Human Tumors. Oxidative Medicine and Cellular Longevity, 2022.

Tsai, H. F., Chang, Y. C., Li, C. H., Chan, M. H., Chen, C. L., Tsai, W. C., & Hsiao, M. (2021). Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling. Cell death discovery, 7(1), 1-12.

Machol, K., Polak, U., Weisz-Hubshman, M., Song, I. W., Chen, S., Jiang, M. M., ... & Lee, B. H. (2021). Molecular alterations due to Col5a1 haploinsufficiency in a mouse model of classic Ehlers–Danlos syndrome. Human molecular genetics.

Zhang, J., Zhang, J., Wang, F., Xu, X., Li, X., Guan, W., ... & Xu, G. (2021). Overexpressed COL5A1 is correlated with tumor progression, paclitaxel resistance, and tumor‐infiltrating immune cells in ovarian cancer. Journal of Cellular Physiology, 236(10), 6907-6919.

Zheng, J., Pang, C. H., Du, W., Wang, L., Sun, L. G., & Xing, Z. Y. (2020). An allele of rs619586 polymorphism in MALAT1 alters the invasiveness of meningioma via modulating the expression of collagen type V alpha (COL5A1). Journal of Cellular and Molecular Medicine, 24(17), 10223-10232.

Wu, M., Sun, Q., Mo, C. H., Pang, J. S., Hou, J. Y., Pang, L. L., ... & Feng, Z. B. (2019). Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry. Oncology Reports, 42(1), 151-175.

Lin, Z., Zeng, J., & Wang, X. (2019). Compound phenotype of osteogenesis imperfecta and Ehlers–Danlos syndrome caused by combined mutations in COL1A1 and COL5A1. Bioscience Reports, 39(7).

Pabalan, N., Tharabenjasin, P., Phababpha, S., & Jarjanazi, H. (2018). Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis. Sports medicine-open, 4(1), 1-11.

Longo, U. G., Margiotti, K., Petrillo, S., Rizzello, G., Fusilli, C., Maffulli, N., ... & Denaro, V. (2018). Genetics of rotator cuff tears: no association of col5a1 gene in a case-control study. BMC Medical Genetics, 19(1), 1-5.

Lv, Z. T., Gao, S. T., Cheng, P., Liang, S., Yu, S. Y., Yang, Q., & Chen, A. M. (2018). Association between polymorphism rs12722 in COL5A1 and musculoskeletal soft tissue injuries: a systematic review and meta-analysis. Oncotarget, 9(20), 15365.

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For research use only. Not intended for any clinical use.

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