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Mouse Anti-COL8A1 Recombinant Antibody (CBLC-LY-015) (CBMAB-C9414-LY)

This product is antibody recognizes COL8A1. The antibody CBLC-LY-015 immunoassay techniques such as: ELISA, WB.
See all COL8A1 antibodies

Summary

Host Animal
Mouse
Specificity
Rabbit
Clone
CBLC-LY-015
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Rabbit
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type VIII Alpha 1 Chain
Introduction
COL8A1 (Collagen Type VIII Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL8A1 include Corneal Dystrophy and Macular Degeneration, Age-Related, 1. Among its related pathways are Integrin Pathway and ERK Signaling.

An important paralog of this gene is COL8A2.
Entrez Gene ID
100009383
UniProt ID
P14282
Function
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
Biological Process
Angiogenesis Source: UniProtKB-KW
Camera-type eye morphogenesis Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Collagen fibril organization Source: Reactome
Endodermal cell differentiation Source: UniProtKB
Epithelial cell proliferation Source: Ensembl
Extracellular matrix organization Source: GO_Central
Positive regulation of cell-substrate adhesion Source: Ensembl
Cellular Location
Basement membrane
PTM
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin.

Battu, P., Sharma, K., Rain, M., Singh, R., & Anand, A. (2021). Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration. Current neurovascular research, 18(2), 181-188.

Bao, H., Li, Z. T., Xu, L. H., Su, T. Y., Han, Y., Bao, M., ... & Qi, Y. X. (2021). Platelet-derived extracellular vesicles increase Col8a1 secretion and vascular stiffness in intimal injury. Frontiers in cell and developmental biology, 9, 404.

Peng, W., Li, J. D., Zeng, J. J., Zou, X. P., Tang, D., Tang, W., ... & Chen, G. (2020). Clinical value and potential mechanisms of COL8A1 upregulation in breast cancer: a comprehensive analysis. Cancer cell international, 20(1), 1-18.

Zhang, L., Jiang, X., Li, Y., Fan, Q., Li, H., Jin, L., ... & Hua, D. (2020). Clinical correlation of Wnt2 and COL8A1 with colon adenocarcinoma prognosis. Frontiers in Oncology, 1504.

Zhou, J., Song, Y., Gan, W., Liu, L., Chen, G., Chen, Z., ... & Cao, Y. (2020). Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells. Oncology Letters, 20(4), 1-1.

Li, X., Wang, Z., Tong, H., Yan, Y., & Li, S. (2018). Effects of COL8A1 on the proliferation of muscle‐derived satellite cells. Cell Biology International, 42(9), 1132-1140.

Shang, J., Wang, F., Chen, P., Wang, X., Ding, F., Liu, S., & Zhao, Q. (2018). Co-expression network analysis identified COL8A1 is associated with the progression and prognosis in human colon adenocarcinoma. Digestive Diseases and Sciences, 63(5), 1219-1228.

Corominas, J., Colijn, J. M., Geerlings, M. J., Pauper, M., Bakker, B., Amin, N., ... & den Hollander, A. I. (2018). Whole-exome sequencing in age-related macular degeneration identifies rare variants in COL8A1, a component of Bruch’s membrane. Ophthalmology, 125(9), 1433-1443.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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