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Mouse Anti-COL9A3 Recombinant Antibody (2B5) (CBMAB-C13234-LY)

This product is antibody recognizes COL9A3 . The antibody 2B5 immunoassay techniques such as: ELISA, WB.
See all COL9A3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B5
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type IX Alpha 3 Chain
Introduction
COL9A3 (Collagen Type IX Alpha 3 Chain) is a Protein Coding gene. Diseases associated with COL9A3 include Epiphyseal Dysplasia, Multiple, 3 and Intervertebral Disc Disease. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent conferring tensile strength. An important paralog of this gene is COL9A2.
Entrez Gene ID
Q14050
UniProt ID
Q14050
Alternative Names
Collagen Type IX Alpha 3 Chain; Collagen Type IX Proteoglycan; Collagen, Type IX, Alpha 3; Collagen IX, Alpha-3 Polypeptide; Collagen Alpha-3(IX) Chain; DJ885L7.4.1; EDM3; MED; IDD;
Function
Structural component of hyaline cartilage and vitreous of the eye.
Biological Process
Collagen fibril organization Source: Reactome
Extracellular matrix organization Source: GO_Central
Female gonad development Source: GO_Central
Male gonad development Source: GO_Central
Cellular Location
Extracellular matrix
Involvement in disease
Multiple epiphyseal dysplasia 3 (EDM3):
A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal.
Intervertebral disc disease (IDD):
Disease susceptibility is associated with variants affecting the gene represented in this entry. Susceptibility to intervertebral disk disease is conferred by variant p.Arg103Trp (PubMed:11308397). A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.
PTM
Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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