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Mouse Anti-COPB2 Recombinant Antibody (CBWJC-2953) (CBMAB-C4100WJ)

This product is a Mouse antibody that recognizes COPB2. This antibody CBWJC-2953 can be used for immunoassay techniques such as: WB, ICC, IP.
See all COPB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Cattle, Dog, Chicken, Hamster, Monkey, Rabbit
Clone
CBWJC-2953
Antibody Isotype
IgG1
Application
WB, ICC, IP

Basic Information

Immunogen
Microtubule-associated protein from goose brain
Specificity
Human, Rat, Cattle, Dog, Chicken, Hamster, Monkey, Rabbit
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coatomer Protein Complex Subunit Beta 2
Introduction
COPB2 (Coatomer Protein Complex Subunit Beta 2) is a Protein Coding gene. Diseases associated with COPB2 include Microcephaly 19, Primary, Autosomal Recessive. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include structural molecule activity.
Entrez Gene ID
Human9276
Cattle281706
Rat60384
Chicken424823
Dog477088
Hamster24267
Monkey717632
Rabbit100353942
UniProt ID
HumanP35606
CattleP35605
RatO35142
ChickenA0A1L1RUT1
DogE2R667
HamsterA0A3Q0D7V9
MonkeyQ4R4I8
RabbitG1SET0
Alternative Names
Coatomer Protein Complex Subunit Beta 2; Coatomer Protein Complex, Subunit Beta 2 (Beta Prime); Coatomer Protein Complex Subunit Beta Prime; Beta-Coat Protein; Beta-Cop; P102;
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity).
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
Intracellular protein transport Source: GO_Central
Intra-Golgi vesicle-mediated transport Source: UniProtKB
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Toxin transport Source: Ensembl
Cellular Location
Cytosol; Golgi apparatus membrane; COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi.
Involvement in disease
Microcephaly 19, primary, autosomal recessive (MCPH19):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH19 affected individuals manifest severe developmental delay, failure to thrive, cortical blindness, and spasticity. Brain imaging show a simplified gyral pattern, thin corpus callosum, slight ventricular dilation, and delayed myelination.

Feng, Y., Lei, X., Zhang, L., Wan, H., Pan, H., Wu, J., ... & Mi, Y. (2021). COPB2: a transport protein with multifaceted roles in cancer development and progression. Clinical and Translational Oncology, 23(11), 2195-2205.

Marom, R., Burrage, L. C., Venditti, R., Clément, A., Blanco-Sánchez, B., Jain, M., ... & Lee, B. (2021). COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay. The American Journal of Human Genetics, 108(9), 1710-1724.

Wu, B., Wu, Y., Guo, X., Yue, Y., Li, Y., He, X., ... & Zhang, S. (2021). An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors. BioMed research international, 2021.

Zhang, J., Wang, X., Li, G., He, J., Lu, Z., Yang, Y., ... & Liu, J. (2021). COPB2: a novel prognostic biomarker that affects progression of HCC. BioMed research international, 2021.

Wang, Y., Xie, G., Li, M., Du, J., & Wang, M. (2020). COPB2 gene silencing inhibits colorectal cancer cell proliferation and induces apoptosis via the JNK/c-Jun signaling pathway. PloS one, 15(11), e0240106.

Bhandari, A., Zheng, C., Sindan, N., Sindan, N., Quan, R., Xia, E., ... & Huang, D. (2019). COPB2 is up‐regulated in breast cancer and plays a vital role in the metastasis via N‐cadherin and Vimentin. Journal of Cellular and Molecular Medicine, 23(8), 5235-5245.

Mi, Y., Sun, C., Wei, B., Sun, F., Guo, Y., Hu, Q., ... & Xia, G. (2018). Coatomer subunit beta 2 (COPB2), identified by label-free quantitative proteomics, regulates cell proliferation and apoptosis in human prostate carcinoma cells. Biochemical and biophysical research communications, 495(1), 473-480.

Li, Z. S., Liu, C. H., Liu, Z., Zhu, C. L., & Huang, Q. (2018). Downregulation of COPB2 by RNAi inhibits growth of human cholangiocellular carcinoma cells. Eur Rev Med Pharmacol Sci, 22(4), 985-992.

Wang, Y., Chai, Z., Wang, M., Jin, Y., Yang, A., & Li, M. (2018). COPB2 suppresses cell proliferation and induces cell cycle arrest in human colon cancer by regulating cell cycle‑related proteins. Experimental and Therapeutic Medicine, 15(1), 777-784.

DiStasio, A., Driver, A., Sund, K., Donlin, M., Muraleedharan, R. M., Pooya, S., ... & Stottmann, R. W. (2017). Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly. Human molecular genetics, 26(24), 4836-4848.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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