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Mouse Anti-COPD Recombinant Antibody (CBWJC-2954) (CBMAB-C4101WJ)

This product is a Mouse antibody that recognizes COPD. This antibody CBWJC-2954 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all COPD antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJC-2954
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset
Introduction
COPD (Pulmonary Disease, Chronic Obstructive, Severe Early-Onset) is a Genetic Locus. Diseases associated with COPD include Pulmonary Disease, Chronic Obstructive.
Entrez Gene ID
Human260431
UniProt ID
HumanP48444
MouseQ5XJY5
Alternative Names
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset;
Function
Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
Golgi localization Source: GO_Central
Intracellular protein transport Source: ProtInc
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Cellular Location
Golgi apparatus membrane; Cytoplasm; COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Involvement in disease
Short stature, rhizomelic, with microcephaly, micrognathia, and developmental delay (SRMMD):
The disease is caused by variants affecting the gene represented in this entry. the skeletal phenotype, that characterizes this disorder, may be due to defective type I collagen transport and reduction of collagen secretion. A disorder characterized by facial dysmorphism, severe micrognathia, microcephaly, rhizomelic short stature, and mild developmental delay.

Szalontai, K., Gémes, N., Furák, J., Varga, T., Neuperger, P., Balog, J. Á., ... & Szebeni, G. J. (2021). Chronic obstructive pulmonary disease: epidemiology, biomarkers, and paving the way to lung cancer. Journal of Clinical Medicine, 10(13), 2889.

Ahmed, E., Fieldes, M., Mianné, J., Bourguignon, C., Nasri, A., Vachier, I., ... & De Vos, J. (2021). Generation of four severe early-onset chronic obstructive pulmonary disease (COPD) patient-derived induced pluripotent stem cell lines from peripheral blood mononuclear cells. Stem Cell Research, 56, 102550.

Brandsma, C. A., Van den Berge, M., Hackett, T. L., Brusselle, G., & Timens, W. (2020). Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine. The Journal of pathology, 250(5), 624-635.

Borràs-Santos, A., Garcia-Aymerich, J., Soler-Cataluña, J. J., Giménez, L. V., Guiral, J. G., Chiaradía, D. R., ... & Cosío, B. G. (2019). Determinants of the Appearance and Progression of Early-Onset Chronic Obstructive Pulmonary Disease in Young Adults. A Case–Control Study With Follow-Up. Archivos de Bronconeumología (English Edition), 55(6), 312-318.

Ejike, C. O., Dransfield, M. T., Hansel, N. N., Putcha, N., Raju, S., Martinez, C. H., & Han, M. K. (2019). Chronic obstructive pulmonary disease in America’s black population. American journal of respiratory and critical care medicine, 200(4), 423-430.

Petersen, H., Sood, A., Polverino, F., Owen, C. A., Pinto-Plata, V., Celli, B. R., & Tesfaigzi, Y. (2018). The course of lung function in middle-aged heavy smokers: incidence and time to early onset of chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 198(11), 1449-1451.

Prokopenko, D., Sakornsakolpat, P., Fier, H. L., Qiao, D., Parker, M. M., McDonald, M. L. N., ... & Cho, M. H. (2018). Whole-genome sequencing in severe chronic obstructive pulmonary disease. American journal of respiratory cell and molecular biology, 59(5), 614-622.

Qiao, D., Ameli, A., Prokopenko, D., Chen, H., Kho, A. T., Parker, M. M., ... & Cho, M. H. (2018). Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Human molecular genetics, 27(21), 3801-3812.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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