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Mouse Anti-COPS5 Recombinant Antibody (2B12) (CBMAB-0130-WJ)

This product is a mouse antibody that recognizes COPS5. The antibody 2B12 can be used for immunoassay techniques such as: WB, IHC, IF, IHC-P.
See all COPS5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
2B12
Antibody Isotype
IgG1
Application
WB, IHC, IF, IHC-P

Basic Information

Immunogen
Full length recombinant protein of human COPS5.
Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
COP9 Signalosome Subunit 5
Introduction
COPS5 (COP9 Signalosome Subunit 5) is a Protein Coding gene. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. Diseases associated with COPS5 include Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are MIF Action Through Endocytic Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER).
Entrez Gene ID
Human10987
Monkey704584
UniProt ID
HumanQ92905
MonkeyF7H142
Alternative Names
CSN5; JAB1; SGN5; MOV-34
Function
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
Biological Process
Exosomal secretion Source: FlyBase
Negative regulation of apoptotic process Source: UniProtKB
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Protein deubiquitination Source: FlyBase
Regulation of cell cycle Source: Ensembl
Regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Regulation of JNK cascade Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Translation Source: ProtInc
Cellular Location
Cytosol; Nucleus; Perinuclear region; Synaptic vesicle. Nuclear localization is diminished in the presence of IFIT3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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