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Mouse Anti-CORO1B Recombinant Antibody (1A10) (CBMAB-C3503-LY)

This product is antibody recognizes CORO1B. The antibody 1A10 immunoassay techniques such as: ELISA.
See all CORO1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A10
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
CORO1B (AAH06449, 1 a.a. ~ 489 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV IVEASGGGAF LVLPLSKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS GSEDCTVMV
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
coronin, actin binding protein, 1B
Introduction
CORO1B (Coronin 1B) is a Protein Coding gene. Diseases associated with CORO1B include Coronin-1A Deficiency. Gene Ontology (GO) annotations related to this gene include identical protein binding and Arp2/3 complex binding. An important paralog of this gene is CORO1C.
Entrez Gene ID
57175
UniProt ID
Q9BR76
Alternative Names
Coronin 1B; CORONIN-2; Coronin, Actin-Binding Protein, 1B; Coronin, Actin Binding Protein, 1B; Coronin-1B;
Function
Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
Biological Process
Actin cytoskeleton organization Source: CACAO
Actin filament branching Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Actin filament organization Source: GO_Central
Cell migration Source: UniProtKB
Cellular response to platelet-derived growth factor stimulus Source: UniProtKB
Endothelial cell chemotaxis Source: UniProtKB
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
Positive regulation of lamellipodium morphogenesis Source: UniProtKB
Protein localization to cell leading edge Source: UniProtKB
Regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Ruffle organization Source: UniProtKB
Wound healing Source: UniProtKB
Cellular Location
Cytoskeleton; Stress fiber. Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.
PTM
Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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