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Mouse Anti-COTL1 Recombinant Antibody (15B14) (CBMAB-C3242-LY)

This product is antibody recognizes COTL1. The antibody 15B14 immunoassay techniques such as: ELISA, WB.
See all COTL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
15B14
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-142 from human COTL1 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Coactosin Like F-Actin Binding Protein 1
Introduction
COTL1 (Coactosin Like F-Actin Binding Protein 1) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme binding and actin binding.
Entrez Gene ID
23406
UniProt ID
Q14019
Alternative Names
Coactosin Like F-Actin Binding Protein 1; CLP; Coactosin-Like F-Actin Binding Protein 1; Coactosin-Like 1 (Dictyostelium); Coactosin-Like Protein; Coactosin-Like 1;
Function
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Biological Process
Defense response to fungus Source: Ensembl
Neutrophil degranulation Source: Reactome
Regulation of actin filament polymerization Source: GO_Central
Cellular Location
Cytoplasm; Nucleus; Cytoskeleton

Mamoor, S. (2021). Differential expression of coactosin like F-actin binding protein 1 in human epithelial ovarian cancer.

Hou, X., Nozumi, M., Nakamura, H., Igarashi, M., & Sugiyama, S. (2021). Coactosin Promotes F-Actin Protrusion in Growth Cones Under Cofilin-Related Signaling Pathway. Frontiers in cell and developmental biology, 9, 1633.

Shao, S., Fan, Y., Zhong, C., Zhu, X., & Zhu, J. (2020). Coactosin-Like Protein (COTL1) Promotes Glioblastoma (GBM) Growth in vitro and in vivo. Cancer Management and Research, 12, 10909.

Scheller, I., Stritt, S., Beck, S., Peng, B., Pleines, I., Heinze, K. G., ... & Nieswandt, B. (2020). Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets. haematologica, 105(6), 1667.

Pei, B., Li, T., Qian, Q., Fan, W., He, X., Zhu, Y., & Xu, L. (2020). Downregulation of microRNA-30c-5p was responsible for cell migration and tumor metastasis via COTL1-mediated microfilament arrangement in breast cancer. Gland surgery, 9(3), 747.

Li, G., Yin, Y., Chen, J., Fan, Y., Ma, J., Huang, Y., ... & Zhao, S. (2018). Coactosin-like protein 1 inhibits neuronal migration during mouse corticogenesis. Journal of Veterinary Science, 19(1), 21-26.

Xia, L., Xiao, X., Liu, W. L., Song, Y., Liu, T. J. J., Li, Y. J., ... & Ben-David, Y. (2018). Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. Oncogene, 37(3), 323-331.

Liu, M., Li, G., Wang, M., Cheng, X., Huang, Y., Xu, M., ... & Zhao, S. (2018). Further studies about Coactosin-like protein-1 affecting the migration of mouse neocortical neurons. Journal of Molecular Histology, 49(5), 519-530.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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