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Mouse Anti-COX5B Recombinant Antibody (16H12H9) (CBMAB-C3375-LY)

This product is antibody recognizes COX5B. The antibody 16H12H9 immunoassay techniques such as: WB, FC.
See all COX5B antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Cattle, Human
Clone
16H12H9
Antibody Isotype
IgG2b
Application
WB, FC

Basic Information

Specificity
Mouse, Rat, Cattle, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome C Oxidase Subunit 5B
Introduction
COX5B (Cytochrome C Oxidase Subunit 5B) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Gene Expression. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity.
Entrez Gene ID
Human1329
Mouse12859
Rat94194
Cattle287012
UniProt ID
HumanP10606
MouseP19536
RatP12075
CattleP00428
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Biological Process
Mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Respiratory gaseous exchange by respiratory system Source: ProtInc
Cellular Location
Mitochondrion inner membrane

Chu, Y. D., Lim, S. N., Yeh, C. T., & Lin, W. R. (2022). COX5B-Mediated Bioenergetic Alterations Modulate Cell Growth and Anticancer Drug Susceptibility by Orchestrating Claudin-2 Expression in Colorectal Cancers. Biomedicines, 10(1), 60.

Shahali, A., Aghaei, N. S. G., Mosharraf, A., Sharestani, S., & Madani, A. (2022). Study of the expression rates of RORA and COX5b genes amongst MS patients compared with healthy individuals as an emerging diagnostic biomarker. Academic Journal of Health Sciencies: Medicina balear, 37(1), 161-165.

Chu, Y. D., Lin, W. R., Lin, Y. H., Kuo, W. H., Tseng, C. J., Lim, S. N., ... & Yeh, C. T. (2020). COX5B-mediated bioenergetic alteration regulates tumor growth and migration by modulating AMPK-UHMK1-ERK cascade in hepatoma. Cancers, 12(6), 1646.

Stein, J., Tenbrock, J., Kristiansen, G., Müller, S. C., & Ellinger, J. (2019). Systematic expression analysis of the mitochondrial respiratory chain protein subunits identifies COX5B as a prognostic marker in clear cell renal cell carcinoma. International Journal of Urology, 26(9), 910-916.

Hinkelbein, J., Böhm, L., Braunecker, S., Adler, C., De Robertis, E., & Cirillo, F. (2017). Decreased tissue COX5B expression and mitochondrial dysfunction during sepsis-induced kidney injury in rats. Oxidative medicine and cellular longevity, 2017.

Hu, T., & Xi, J. (2017). Identification of COX5B as a novel biomarker in high-grade glioma patients. OncoTargets and therapy, 10, 5463.

Gao, S. P., Sun, H. F., Fu, W. Y., Li, L. D., Zhao, Y., Chen, M. T., & Jin, W. (2017). High expression of COX5B is associated with poor prognosis in breast cancer. Future Oncology, 13(19), 1711-1719.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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