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Mouse Anti-COX7A1 Recombinant Antibody (CBYY-C3205) (CBMAB-C4648-YY)

This product is mouse antibody that recognizes COX7A1. The antibody CBYY-C3205 can be used for immunoassay techniques such as: WB
See all COX7A1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Cattle
Clone
CBYY-C3205
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Mouse, Rat, Cattle
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
IgG fraction
Buffer
1 mg/mL
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome C Oxidase Subunit 7A1
Entrez Gene ID
Mouse12865
Rat100910772
Cattle338086
UniProt ID
MouseP56392
RatM0R5K3
CattleP07470
Alternative Names
Claudin 1; Senescence-Associated Epithelial Membrane Protein 1; SEMP1; CLD1; Senescence-Associated Epithelial Membrane Protein; Claudin-1; ILVASC;
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Biological Process
Generation of precursor metabolites and energy Source: ProtInc
Mitochondrial respirasome assembly Source: GO_Central
Oxidative phosphorylation Source: UniProtKB-UniPathway
Regulation of oxidative phosphorylation Source: GO_Central
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial matrix: 22-46
Helical: 47-75
Mitochondrial intermembrane: 76-79
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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