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Rabbit Anti-COX8C Recombinant Antibody (CBWJC-2992) (CBMAB-C4147WJ)

This product is a Rabbit antibody that recognizes COX8C. This antibody CBWJC-2992 can be used for immunoassay techniques such as: WB.
See all COX8C antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBWJC-2992
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome C Oxidase Subunit 8C
Introduction
COX8C (Cytochrome C Oxidase Subunit 8C) is a Protein Coding gene. Diseases associated with COX8C include Tethered Spinal Cord Syndrome. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and AMPK Enzyme Complex Pathway. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity.
Entrez Gene ID
Human341947
Mouse75483
Rat360229
UniProt ID
HumanQ7Z4L0
MouseA6H666
RatQ7TNN2
Alternative Names
Cytochrome C Oxidase Subunit 8C; Cytochrome C Oxidase Subunit VIIIC; Cytochrome C Oxidase Subunit 8-3; COX VIII-3; COX8-3; Cytochrome C Oxidase Polypeptide VIII Isoform 3; Cytochrome C Oxidase Subunit 8C, Mitochondrial;
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Biological Process
Oxidative phosphorylation Source: UniProtKB-UniPathway
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial matrix: 30-40
Helical: 41-64
Mitochondrial intermembrane: 65-72
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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