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Mouse Anti-CPA1 Recombinant Antibody (CBXC-2101) (CBMAB-C4473-CQ)

This product is a mouse antibody that recognizes CPA1. The antibody CBXC-2101 can be used for immunoassay techniques such as: WB, IHC, IF, FC.
See all CPA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2101
Antibody Isotype
IgG2a
Application
WB, IHC, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human CPA1(NP_001859)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carboxypeptidase A1
Introduction
CPA1 (Carboxypeptidase A1) is a Protein Coding gene. Diseases associated with CPA1 include Pancreatitis and Borna Disease. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and exopeptidase activity. An important paralog of this gene is CPA2.
Entrez Gene ID
UniProt ID
Alternative Names
Carboxypeptidase A1; Carboxypeptidase A1 (Pancreatic); Pancreatic Carboxypeptidase A; EC 3.4.17.1; CPA; EC 3.4.17;
Function
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:8806703).

Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).
Biological Process
Leukotriene metabolic process Source: UniProtKB
Proteolysis Source: GO_Central
Cellular Location
Secreted

Uhlig, R., Contreras, H., Weidemann, S., Gorbokon, N., Menz, A., Büscheck, F., ... & Clauditz, T. S. (2022). Carboxypeptidase A1 (CPA1) immunohistochemistry is highly sensitive and specific for acinar cell carcinoma (ACC) of the pancreas. The American journal of surgical pathology, 46(1), 97-104.

Wang, W., Tang, W., Wang, X., Liu, W., & Zhu, F. (2022). Genes from Carboxypeptidase A, glutathione S-transferase, and cytochrome b families were found involved in lead transport in insect Musca domestica. Ecotoxicology and Environmental Safety, 230, 113113.

Naureen, U., Arif, R., Akram, F., Shahid, M. G., & Saleem, M. (2021). Genetic Diversity Analysis and In Silico Investigation of Post-Translational Modifications of Carboxypeptidase A1 (CpA1) in Sordaria fimicola. International Journal of Agriculture and Biology, 25(2), 475-482.

Said, S., Kurtin, P. J., Nasr, S. H., Graham, R. P., Dasari, S., Vrana, J. A., ... & Wu, T. T. (2020). Carboxypeptidase A1 and regenerating islet-derived 1α as new markers for pancreatic acinar cell carcinoma. Human Pathology, 103, 120-126.

Orekhova, A., Geisz, A., & Sahin-Tóth, M. (2020). Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(4), G694-G704.

Hegyi, E., & Sahin-Tóth, M. (2019). Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice. Gut, 68(2), 301-312.

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., ... & Goggins, M. (2018). Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proceedings of the National Academy of Sciences, 115(18), 4767-4772.

Wu, H., Zhou, D. Z., Berki, D., Geisz, A., Zou, W. B., Sun, X. T., ... & Liao, Z. (2017). No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort. Human mutation, 38(8), 959-963.

Kujko, A. A., Berki, D. M., Oracz, G., Wejnarska, K., Antoniuk, J., Wertheim-Tysarowska, K., ... & Rygiel, A. M. (2017). A novel p. Ser282Pro CPA1 variant is associated with autosomal dominant hereditary pancreatitis. Gut, 66(9), 1728-1730.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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