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Mouse Anti-CPA3 Recombinant Antibody (CBFYM-1021) (CBMAB-M1173-FY)

This product is mouse antibody that recognizes CPA3. The antibody CBFYM-1021 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all CPA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1021
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Carboxypeptidase A3, Mast Cell
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
carboxypeptidase A3 (mast cell)
Introduction
CPA3 is a Protein Coding gene. Diseases associated with CPA3 include Asthma. Among its related pathways are Peptide hormone metabolism and Collagen chain trimerization. Gene Ontology annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is CPB1.
Entrez Gene ID
1359
UniProt ID
P15088
Alternative Names
Carboxypeptidase A3; Carboxypeptidase A3 (Mast Cell); Mast Cell Carboxypeptidase A; Tissue Carboxypeptidase A; MC-CPA; EC 3.4.17.1; EC 3.4.1
Biological Process
Angiotensin maturation Source: Reactome
Proteolysis Source: GO_Central
Cellular Location
Secretory vesicle. Secretory granules.

Akula, S., Hellman, L., Avilés, F. X., & Wernersson, S. (2022). Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Developmental & Comparative Immunology, 127, 104273.

Atiakshin, D., Kostin, A., Trotsenko, I., Samoilova, V., Buchwalow, I., & Tiemann, M. (2022). Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells. Cells, 11(3), 570.

Siddhuraj, P., Clausson, C. M., Sanden, C., Alyamani, M., Kadivar, M., Marsal, J., ... & Erjefält, J. S. (2021). Lung mast cells have a high constitutive expression of carboxypeptidase A3 mRNA that is independent from granule-stored CPA3. Cells, 10(2), 309.

Soria‐Castro, R., Meneses‐Preza, Y. G., Rodríguez‐López, G. M., Romero‐Ramírez, S., Sosa‐Hernández, V. A., Cervantes‐Díaz, R., ... & Chacón‐Salinas, R. (2021). Severe COVID‐19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin. Journal of leukocyte biology, 110(3), 425-431.

Hämäläinen, S., Kareinen, L., Sukura, A., & Kareinen, I. (2021). Carboxypeptidase A3 expression in canine mast cell tumors and tissue-resident mast cells. Veterinary pathology, 03009858211062636.

Magnúsdóttir, E. I., Grujic, M., Bergman, J., Pejler, G., & Lagerström, M. C. (2020). Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1. Journal of neuroinflammation, 17(1), 1-11.

Lewicki, Ł., Siebert, J., Koliński, T., Piekarska, K., Reiwer-Gostomska, M., Targoński, R., ... & Marek-Trzonkowska, N. (2019). Mast cell derived carboxypeptidase A3 is decreased among patients with advanced coronary artery disease. Cardiology Journal, 26(6), 680-686.

Abadalkareem, R., Lau, L. C., Abdelmotelb, A., Zhou, X., Eren, E., & Walls, A. F. (2017). Mast cell tryptase and carboxypeptidase A3 (CPA3) as markers for predicting susceptibility to severe allergic drug reactions. Journal of Allergy and Clinical Immunology, 139(2), AB39.

Grujic, M., Paivandy, A., Gustafson, A. M., Thomsen, A. R., Öhrvik, H., & Pejler, G. (2017). The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung. Oncotarget, 8(15), 25066.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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