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Mouse Anti-CPLX4 Recombinant Antibody (171H8) (CBMAB-C2755-CN)

This product is a Mouse antibody that recognizes CPLX4. The antibody 171H8 can be used for immunoassay techniques such as: IHC, WB.
See all CPLX4 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Mouse
Clone
171H8
Application
IHC, WB

Basic Information

Specificity
Rat, Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Complexin 4
Introduction
CPLX4 (Complexin 4) is a Protein Coding gene. Among its related pathways are Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNARE binding. An important paralog of this gene is CPLX3.
Entrez Gene ID
Mouse225644
Rat361342
UniProt ID
MouseQ80WM3
RatD3ZM85
Alternative Names
Complexin 4; Complexin IV; CPX IV; Complexin-4; CPX-IV; CPXIV;
Function
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity).

Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity).

Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity).

Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca2+ vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca2+ vesicle release (By similarity).
Biological Process
Regulation of neurotransmitter secretion Source: GO_Central
Response to stimulus Source: UniProtKB-KW
Synaptic vesicle exocytosis Source: GO_Central
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane; Synapse. Enriched at the synaptic terminal.
PTM
Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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