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Mouse Anti-CREB3L3 Antibody (2D10) (CBMAB-0240-YC)

Provided herein are mouse monoclonal antibodies against Human CREB3L3. The antibody clone 2D10 can be used for immunoassay techniques, such as ELISA and IP.
See all CREB3L3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D10
Antibody Isotype
IgG2b
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CREB3L3
Introduction
CREB3L3 (cAMP responsive element binding protein 3-like 3) is a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. CREB3L3 is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. Besides, CREB3L3 binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression.
Entrez Gene ID
84699
UniProt ID
Q68CJ9
Alternative Names
CREB-H
Function
Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity).

May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity).
Biological Process
Endoplasmic reticulum unfolded protein response Source: Reactome
Positive regulation of acute inflammatory response Source: ParkinsonsUK-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane
Processed cyclic AMP-responsive element-binding protein 3-like protein 3: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Topology
Cytoplasmic: 1-322
Helical: 323-343
Lumenal: 344-461
PTM
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).
N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans.
Ubiquitinated at Lys-294 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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