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Mouse Anti-CREBL2 Antibody (1A11) (CBMAB-0244-YC)

Provided herein are mouse monoclonal antibodies against Human CREBL2. The antibody clone 1A11 can be used for immunoassay techniques, such as WB and MA.
See all CREBL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A11
Antibody Isotype
IgG1
Application
WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cAMP responsive element binding protein-like 2
Introduction
CREBL2 (cAMP responsive element binding protein-like 2) shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. CREBL2 has DNA binding capabilities and may act as a tumor suppressor gene.
Entrez Gene ID
1389
UniProt ID
O60519
Alternative Names
CREBL2; cAMP responsive element binding protein-like 2
Function
Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.
Biological Process
Cell cycle Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Positive regulation of fat cell differentiation Source: UniProtKB
Positive regulation of glucose import Source: UniProtKB
Positive regulation of lipid biosynthetic process Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Signal transduction Source: ProtInc
Transcription, DNA-templated Source: ProtInc
Cellular Location
Nucleus
PTM
Phosphorylated by AMPK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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